Association of Atrial Fibrillation With Cognitive Decline and Dementia Over 20 Years: The ARIC-NCS (Atherosclerosis Risk in Communities Neurocognitive Study)

被引：110

作者：

Chen, Lin Y. ^{[1
]}

Norby, Faye L. ^{[2
]}

Gottesman, Rebecca F. ^{[3
]}

Mosley, Thomas H. ^{[4
]}

Soliman, Elsayed Z. ^{[5
]}

Agarwal, Sunil K. ^{[6
]}

Loehr, Laura R. ^{[7
]}

Folsom, Aaron R. ^{[2
]}

Coresh, Josef ^{[8
]}

Alonso, Alvaro ^{[9
]}

机构：

[1] Univ Minnesota, Sch Med, Dept Med, Cardiovasc Div, 420 Delaware St SE,MMC 508, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[4] Univ Mississippi, Sch Med, Dept Neurol, Jackson, MS 39216 USA

[5] Wake Forest Sch Med, Epidemiol Cardiol Res Ctr EPICARE, Winston Salem, NC USA

[6] Mt Sinai Sch Med, Dept Med, New York, NY USA

[7] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA

[8] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[9] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA

来源：

JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2018年 / 7卷 / 06期

关键词：

atrial fibrillation; cognition; cohort study; dementia; epidemiology; CONGESTIVE-HEART-FAILURE; ALZHEIMERS-DISEASE; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; CEREBRAL INFARCTS; APOLIPOPROTEIN-E; STROKE; POPULATION; IMPAIRMENT; PERFORMANCE;

D O I：

10.1161/JAHA.117.007301

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background-Previous studies have reported that atrial fibrillation (AF) is associated with cognitive decline and dementia. These studies, however, had limited follow-up, were based mostly on white and highly selected populations, and did not account for attrition. We evaluated the association of incident AF with 20-year change in cognitive performance (accounting for attrition) and incident dementia in the ARIC (Atherosclerosis Risk in Communities) Study. Methods and Results-We analyzed data from 12515 participants (mean age, 56.9 [SD, 5.7] years in 1990-1992; 56% women and 24% black) from 1990 to 1992 through 2011 to 2013. Incident AF was ascertained from study ECGs and hospital discharge codes. Cognitive tests were performed in 1990 to 1992, 1996 to 1998, and 2011 to 2013. Incident dementia was clinician adjudicated. We used generalized estimating equations and Cox proportional hazards models to assess the association of time-dependent AF with change in Z scores of cognitive tests and incident dementia, respectively. During 20 years, 2106 participants developed AF and 1157 participants developed dementia. After accounting for cardiovascular risk factors, including ischemic stroke, the average decline over 20 years in global cognitive Z score was 0.115 (95% confidence interval, 0.014-0.215) greater in participants with AF than in those without AF. Further adjustment for attrition by multiple imputation by chained equations strengthened the association. In addition, incident AF was associated with an increased risk of dementia (hazard ratio, 1.23; 95% confidence interval, 1.04-1.45), after adjusting for cardiovascular risk factors, including ischemic stroke. Conclusions-AF is associated with greater cognitive decline and increased risk of dementia, independent of ischemic stroke. Because cognitive decline is a precursor to dementia, our findings prompt further investigation to identify specific treatments for AF that will delay the trajectory of cognitive decline and, thus, prevent dementia in patients with AF.

引用

页数：13

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