Ivermectin Protects against Monosodium Glutamate-Induced Excitotoxicity in the Rat

被引:2
作者
Arise, Rotimi O. [1 ]
Arise, Abimbola K. [2 ]
Oyewole, Oluwole, I [3 ]
Malomo, Sylvia O. [1 ]
机构
[1] Univ Ilorin, Dept Biochem, Ilorin, Nigeria
[2] Univ Ilorin, Dept Home Econ & Food Sci, Ilorin, Nigeria
[3] Osun State Univ, Dept Chem Sci, Biochem Unit, Osogbo, Nigeria
关键词
monosodium glutamate; ivermectin; excitotoxicity; oxidative stress; glutamate channels; GLUTATHIONE-S-TRANSFERASE; OXIDATIVE STRESS; LIPID-PEROXIDATION; BRAIN; DAMAGE; ACTIVATION; RECEPTORS; MECHANISM; CELLS; ACIDS;
D O I
10.2478/afmnai-2019-0004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Monosodium glutamate (MSG), an established excitotoxic food additive, has been found to induce oxidative stress in all tissues. To examine the protective effects of ivennectin on MSG-induced excitotoxicity, 28 male albino rats were randomized into four groups. Group 1, the control, received 1 ml of oral distilled water, group 2 was administered an aqueous solution of MSG (4 mg/kg body weight/day). Group 3 was co-administered with the same dose of MSG and 0.4 mg/kg body weight of ivennectin, while group 4 rats received orally the same dose of MSG for 2 weeks, after which ivermectin was administered orally for 1 week Administration of MSG orally for 21 days and for 14 days, followed by oral administration of ivermectin for 7 days, significantly increased (p < 0.05) glutathione-S-transferase, nitric oxide synthase, superoxide dismutase and catalase activities as well as malondialdehyde and intracellular Ca2+ concentrations while Na+ - K+-ATPase, Ca2+ - Mg2+ - ATPase, acid phosphatase (ACP) and alkaline phosphatase (ALP) activities were significantly reduced (p < 0.05) compared to the controL However, co-administration of MSG and ivennectin for 21 days did not show any significant difference (p > 0.05) in all the parameters studied compared to the control. This result suggests that ivermectin may protect against MSG-induced excitotoxicity in rats.
引用
收藏
页码:38 / 47
页数:10
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