A Reliable Synthesis of 3-Amino-5-Alkyl and 5-Amino-3-Alkyl Isoxazoles

被引：20

作者：

Johnson, Leland ^{[1
]}

Powers, James ^{[1
]}

Ma, Fupeng ^{[1
]}

Jendza, Keith ^{[1
]}

Wang, Bing ^{[1
]}

Meredith, Erik ^{[1
]}

Mainolfi, Nello ^{[1
]}

机构：

[1] Novartis Inst Biomed Res, Cambridge, MA 02139 USA

来源：

SYNTHESIS-STUTTGART | 2013年 / 45卷 / 02期

关键词：

heterocycles; regioselectivity; condensation; medicinal chemistry; imines; 3-AMINOISOXAZOLES; HYDROXYLAMINE;

D O I：

10.1055/s-0032-1317935

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A reliable procedure that can be used to access a wide range of 3-amino-5-alkyl and 5-amino-3-alkyl isoxazoles was developed. Reaction temperature and pH were key factors that determined the regioselectivity of the two reactions.

引用

页码：171 / 173

页数：3

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