The primary headaches: genetics, epigenetics and a behavioural genetic model

被引:40
作者
Montagna, Pasquale [1 ]
机构
[1] Univ Bologna, Sch Med, Dept Neurol Sci, I-40123 Bologna, Italy
关键词
Migraine; Tension-type headache; Cluster headache; Genetics; Epigenetics;
D O I
10.1007/s10194-008-0026-x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The primary headaches, migraine with ( MA) and without aura ( MO) and cluster headache, all carry a substantial genetic liability. Familial hemiplegic migraine (FHM), an autosomal dominant mendelian disorder classified as a subtype of MA, is due to mutations in genes encoding neural channel subunits. MA/MO are considered multifactorial genetic disorders, and FHM has been proposed as a model for migraine aetiology. However, a review of the genetic studies suggests that the FHM genes are not involved in the typical migraines and that FHM should be considered as a syndromic migraine rather than a subtype of MA. Adopting the concept of syndromic migraine could be useful in understanding migraine pathogenesis. We hypothesise that epigenetic mechanisms play an important role in headache pathogenesis. A behavioural model is proposed, whereby the primary headaches are construed as behaviours, not symptoms, evolutionarily conserved for their adaptive value and engendered out of a genetic repertoire by a network of pattern generators present in the brain and signalling homeostatic imbalance. This behavioural model could be incorporated into migraine genetic research.
引用
收藏
页码:57 / 69
页数:13
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