Nonlinear Nanomedecine: Harmonic Nanoparticles toward Targeted Diagnosis and Therapy

被引：71

作者：

Bonacina, Luigi ^{[1
]}

机构：

[1] Univ Geneva, GAP Biophoton, CH-1211 Geneva 4, Switzerland

来源：

MOLECULAR PHARMACEUTICS | 2013年 / 10卷 / 03期

关键词：

nonlinear microscopy; nanoparticles; optical markers; theranostic; IRON-OXIDE NANOPARTICLES; 2ND-HARMONIC GENERATION; OPTICAL-PROPERTIES; SHG NANOPROBES; STEM-CELLS; NANOCRYSTALS; PROBES; RADIATION; 2-PHOTON; SPECTROSCOPY;

D O I：

10.1021/mp300523e

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Harmonic nanoparticles were first introduced in 2006 as biomarkers for nonlinear imaging. This review provides a general explanation of the physical mechanism at the basis of this novel approach, highlighting its benefits and the complementarity to fluorescent/luminescent labels. A series of application examples from the very recent literature are reported, ranging from in vitro cell monitoring to the first proofs of in vivo imaging and rare event detection in physiological fluids.

引用

页码：783 / 792

页数：10

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