The methoxylation of N-formylpyrrolidine in a microfluidic electrolysis cell for routine synthesis

被引：39
作者：
Kuleshova, Jekaterina [1 ]
Hill-Cousins, Joseph T. [1 ]
Birkin, Peter R. [1 ]
Brown, Richard C. D. [1 ]
Pletcher, Derek [1 ]
Underwood, Toby J. [2 ]
机构：
[1] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England
[2] Pfizer Ltd, Sandwich CT13 9NJ, Kent, England
来源：
ELECTROCHIMICA ACTA | 2012年 / 69卷
基金：
英国工程与自然科学研究理事会;
关键词：
Microflow reactor; Electrolysis cell; Methoxylation reactions; Oxidation; ELECTROORGANIC SYNTHESIS; PAIRED ELECTROSYNTHESIS; REACTOR; DERIVATIVES;
D O I：
10.1016/j.electacta.2012.02.093
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
A single channel microfluidic electrolysis cell being developed for application alongside other routine microfluidic operations in the laboratory has been applied to the methoxylation of N-formylpyrrolidine. It is shown that very high conversions (>>90%) in a single pass can be achieved and it is possible to obtain several grams of product per hour with a good selectivity in optimised conditions. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：197 / 202
页数：6
相关论文
共 27 条
  • [21] Paired electrosynthesis: micro-flow cell processes with and without added electrolyte
    Paddon, CA
    Pritchard, GJ
    Thiemann, T
    Marken, F
    [J]. ELECTROCHEMISTRY COMMUNICATIONS, 2002, 4 (10) : 825 - 831
  • [22] Towards paired and coupled electrode reactions for clean organic microreactor electrosyntheses
    Paddon, Christopher A.
    Atobe, Mahito
    Fuchigami, Toshio
    He, Ping
    Watts, Paul
    Haswell, Stephen J.
    Pritchard, Gareth J.
    Bull, Steven D.
    Marken, Frank
    [J]. JOURNAL OF APPLIED ELECTROCHEMISTRY, 2006, 36 (06) : 617 - 634
  • [23] A method for fabricating microfluidic electrochemical reactors
    Simms, Ryan
    Dubinsky, Stanislav
    Yudin, Andrei
    Kumacheva, Eugenia
    [J]. LAB ON A CHIP, 2009, 9 (16) : 2395 - 2397
  • [24] Cation flow method: A new approach to electrochemical conventional and combinatorial organic syntheses using electrochemical microflow systems
    Suga, S
    Okajima, M
    Fujiwara, K
    Yoshida, J
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (32) : 7941 - 7942
  • [25] Trends in organic electrosynthesis
    Utley, J
    [J]. CHEMICAL SOCIETY REVIEWS, 1997, 26 (03) : 157 - 167
  • [26] Flash chemistry using electrochemical method and microsystems
    Yoshida, J
    [J]. CHEMICAL COMMUNICATIONS, 2005, (36) : 4509 - 4516
  • [27] Electrochemical microstructured reactors: design and application in organic synthesis
    Ziogas, A.
    Kolb, G.
    O'Connell, M.
    Attour, A.
    Lapicque, F.
    Matlosz, M.
    Rode, S.
    [J]. JOURNAL OF APPLIED ELECTROCHEMISTRY, 2009, 39 (12) : 2297 - 2313
123