The methoxylation of N-formylpyrrolidine in a microfluidic electrolysis cell for routine synthesis

被引：39
作者：
Kuleshova, Jekaterina [1 ]
Hill-Cousins, Joseph T. [1 ]
Birkin, Peter R. [1 ]
Brown, Richard C. D. [1 ]
Pletcher, Derek [1 ]
Underwood, Toby J. [2 ]
机构：
[1] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England
[2] Pfizer Ltd, Sandwich CT13 9NJ, Kent, England
来源：
ELECTROCHIMICA ACTA | 2012年 / 69卷
基金：
英国工程与自然科学研究理事会;
关键词：
Microflow reactor; Electrolysis cell; Methoxylation reactions; Oxidation; ELECTROORGANIC SYNTHESIS; PAIRED ELECTROSYNTHESIS; REACTOR; DERIVATIVES;
D O I：
10.1016/j.electacta.2012.02.093
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
A single channel microfluidic electrolysis cell being developed for application alongside other routine microfluidic operations in the laboratory has been applied to the methoxylation of N-formylpyrrolidine. It is shown that very high conversions (>>90%) in a single pass can be achieved and it is possible to obtain several grams of product per hour with a good selectivity in optimised conditions. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：197 / 202
页数：6
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