Convalescent plasma in Covid-19: Possible mechanisms of action

被引：334

作者：

Rojas, Manuel ^{[1
]}

Rodriguez, Yhojan ^{[1
,2
]}

Monsalve, Diana M. ^{[1
]}

Acosta-Ampudia, Yeny ^{[1
]}

Camacho, Bernardo ^{[3
]}

Esteban Gallo, Juan ^{[4
]}

Rojas-Villarraga, Adriana ^{[5
]}

Ramirez-Santana, Carolina ^{[1
]}

Diaz-Coronado, Juan C. ^{[6
]}

Manrique, Ruben ^{[7
]}

Mantilla, Ruben D. ^{[1
,2
]}

Shoenfeld, Yehuda ^{[8
,9
]}

Anaya, Juan-Manuel ^{[1
,2
]}

机构：

[1] Univ Rosario, Ctr Autoimmune Dis Res CREA, Sch Med & Hlth Sci, Carrera 26-63-B-51, Bogota 110010, Colombia

[2] Clin Occidente, Bogota, Colombia

[3] Inst Dist Ciencia Biotecnol & Invest Salud, IDCBIS, Bogota, Colombia

[4] Univ CES, Genoma CES, Medellin, Colombia

[5] Fdn Univ Ciencias Salud FUCS, Bogota, Colombia

[6] Univ CES, Internal Med Dept, Medellin, Colombia

[7] Univ CES, Epidemiol & Biostat Res Grp, Medellin, Colombia

[8] Tel Aviv Univ, Zabludowicz Ctr Autoimmune Dis, Sheba Med Ctr, Tel Aviv, Israel

[9] St Petersburg State Univ, Lab Mosa Autoimmun, St Petersburg, Russia

来源：

AUTOIMMUNITY REVIEWS | 2020年 / 19卷 / 07期

关键词：

Coronavirus; COVID-19; SARS-Cov-2; Convalescent plasma; Cytokines; Intravenous immunoglobulins; Neutralizing antibodies; ACE-2; receptor; INTRAVENOUS IMMUNOGLOBULIN TREATMENT; AVIAN INFLUENZA; B-CELLS; CLINICAL CHARACTERISTICS; SPIKE PROTEIN; IGG IVIG; T-CELLS; CORONAVIRUS; INHIBITION; EXPRESSION;

D O I：

10.1016/j.autrev.2020.102554

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible of the coronavirus disease 2019 (COVID-19) pandemic. Therapeutic options including antimalarials, antivirals, and vaccines are under study. Meanwhile the current pandemic has called attention over old therapeutic tools to treat infectious diseases. Convalescent plasma (CP) constitutes the first option in the current situation, since it has been successfully used in other coronaviruses outbreaks. Herein, we discuss the possible mechanisms of action of CP and their repercussion in COVID-19 pathogenesis, including direct neutralization of the virus, control of an overactive immune system (Le., cytokine storm, Th1/Th17 ratio, complement activation) and immunomodulation of a hypercoagulable state. All these benefits of CP are expected to be better achieved if used in non-critically hospitalized patients, in the hope of reducing morbidity and mortality.

引用

页数：9

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