Gastroprotective Effect of Stress Preconditioning: Involvement of Glucocorticoids

被引：13
作者：
Filaretova, Ludmila [1 ]
机构：
[1] Russian Acad Sci, Pavlov Inst Physiol, Lab Expt Endocrinol, Nab Makarova 6, St Petersburg 199034, Russia
来源：
CURRENT PHARMACEUTICAL DESIGN | 2017年 / 23卷 / 27期
基金：
俄罗斯科学基金会;
关键词：
Preconditioning; stress; gastric mucosa; injury; gastroprotection; glucocorticoids; THYROTROPIN-RELEASING-HORMONE; GASTRIC-MUCOSAL PROTECTION; ISCHEMIA-REPERFUSION INJURY; CHRONIC MILD RESTRAINT; ADAPTIVE CYTOPROTECTION; ULCER FORMATION; RAT; PROSTAGLANDINS; MECHANISMS; COLD;
D O I：
10.2174/1381612823666170215145125
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Stress plays a leading role in maintaining the physical health of the body. Various health effects of preconditioning mild stress strongly confirm this statement. Preconditioning mild stress, which is everyday event of animal and human life, may attenuate the development and aggravation of diseases including such widespread pathology as gastric ulceration. Preconditioning mild stress may diminish gastric injury formation caused by severe stress. Gastroprotective influence of preconditioning mild stress is known to be mediated by prostaglandins. In the present article, we focus on the data suggesting that glucocorticoids released in response to preconditioning mild stressor are important players of gastroprotective influence of preconditioning stress.
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收藏
页码：3923 / 3927
页数：5
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