Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus

被引：172

作者：

Messaoudi, Ilhem ^{[1
]}

Amarasinghe, Gaya K. ^{[2
]}

Basler, Christopher F. ^{[3
]}

机构：

[1] Univ Calif Riverside, Sch Med, Riverside, CA 92521 USA

[2] Washington Univ, Div Biol & Biomed Sci, St Louis, MO 63110 USA

[3] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2015年 / 13卷 / 11期

基金：

美国国家卫生研究院;

关键词：

DOUBLE-STRANDED-RNA; INTERFERON-INDUCED PROTEIN; HEMORRHAGIC-FEVER; VP35; PROTEIN; DENDRITIC CELLS; RIG-I; HUMAN MACROPHAGES; STRUCTURAL BASIS; PRIMATE MODELS; VP40;

D O I：

10.1038/nrmicro3524

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in West Africa. Filovirus disease is characterized by uncontrolled virus replication and the activation of host responses that contribute to pathogenesis. Underlying these phenomena is the potent suppression of host innate antiviral responses, particularly the type! interferon response, by viral proteins, which allows high levels of viral replication. In this Review, we describe the mechanisms used by filoviruses to block host innate immunity and discuss the links between immune evasion and filovirus pathogenesis.

引用

页码：663 / 676

页数：14

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