Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus

被引：177

作者：

Messaoudi, Ilhem ^{[1
]}

Amarasinghe, Gaya K. ^{[2
]}

Basler, Christopher F. ^{[3
]}

机构：

[1] Univ Calif Riverside, Sch Med, Riverside, CA 92521 USA

[2] Washington Univ, Div Biol & Biomed Sci, St Louis, MO 63110 USA

[3] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2015年 / 13卷 / 11期

基金：

美国国家卫生研究院;

关键词：

DOUBLE-STRANDED-RNA; INTERFERON-INDUCED PROTEIN; HEMORRHAGIC-FEVER; VP35; PROTEIN; DENDRITIC CELLS; RIG-I; HUMAN MACROPHAGES; STRUCTURAL BASIS; PRIMATE MODELS; VP40;

D O I：

10.1038/nrmicro3524

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in West Africa. Filovirus disease is characterized by uncontrolled virus replication and the activation of host responses that contribute to pathogenesis. Underlying these phenomena is the potent suppression of host innate antiviral responses, particularly the type! interferon response, by viral proteins, which allows high levels of viral replication. In this Review, we describe the mechanisms used by filoviruses to block host innate immunity and discuss the links between immune evasion and filovirus pathogenesis.

引用

页码：663 / 676

页数：14

共 158 条

[1] Ebola Virus Enters Host Cells by Macropinocytosis and Clathrin-Mediated Endocytosis [J].

Aleksandrowicz, Paulina ;

Marzi, Andrea ;

Biedenkopf, Nadine ;

Beimforde, Nadine ;

Becker, Stephan ;

Hoenen, Thomas ;

Feldmann, Heinz ;

Schnittler, Hans-Joachim .

JOURNAL OF INFECTIOUS DISEASES, 2011, 204 :S957-S967

[2] ORAL SHEDDING OF MARBURG VIRUS IN EXPERIMENTALLY INFECTED EGYPTIAN FRUIT BATS (ROUSETTUS AEGYPTIACUS) [J].

Amman, Brian R. ;

Jones, Megan E. B. ;

Sealy, Tara K. ;

Uebelhoer, Luke S. ;

Schuh, Amy J. ;

Bird, Brian H. ;

Coleman-McCray, JoAnn D. ;

Martin, Brock E. ;

Nichol, Stuart T. ;

Towner, Jonathan S. .

JOURNAL OF WILDLIFE DISEASES, 2015, 51 (01) :113-124

[3] Seasonal Pulses of Marburg Virus Circulation in Juvenile Rousettus aegyptiacus Bats Coincide with Periods of Increased Risk of Human Infection [J].

Amman, Brian R. ;

Carroll, Serena A. ;

Reed, Zachary D. ;

Sealy, Tara K. ;

Balinandi, Stephen ;

Swanepoel, Robert ;

Kemp, Alan ;

Erickson, Bobbie Rae ;

Comer, James A. ;

Campbell, Shelley ;

Cannon, Deborah L. ;

Khristova, Marina L. ;

Atimnedi, Patrick ;

Paddock, Christopher D. ;

Crockett, Rebekah J. Kent ;

Flietstra, Timothy D. ;

Warfield, Kelly L. ;

Unfer, Robert ;

Katongole-Mbidde, Edward ;

Downing, Robert ;

Tappero, Jordan W. ;

Zaki, Sherif R. ;

Rollin, Pierre E. ;

Ksiazek, Thomas G. ;

Nichol, Stuart T. ;

Towner, Jonathan S. .

PLOS PATHOGENS, 2012, 8 (10)

[4] Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients [J].

Baize, S ;

Leroy, EM ;

Georges-Courbot, MC ;

Capron, M ;

Lansoud-Soukate, J ;

Debré, P ;

Fisher-Hoch, SP ;

McCormick, JB ;

Georges, AJ .

NATURE MEDICINE, 1999, 5 (04) :423-426

[5] Inflammatory responses in Ebola virus-infected patients [J].

Baize, S ;

Leroy, EM ;

Georges, AJ ;

Georges-Courbot, MC ;

Capron, M ;

Bedjabaga, I ;

Lansoud-Soukate, J ;

Mavoungou, E .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2002, 128 (01) :163-168

[6] Emergence of Zaire Ebola Virus Disease in Guinea [J].

Baize, Sylvain ;

Pannetier, Delphine ;

Oestereich, Lisa ;

Rieger, Toni ;

Koivogui, Lamine ;

Magassouba, N'Faly ;

Soropogui, Barre ;

Sow, Mamadou Saliou ;

Keita, Sakoba ;

De Clerck, Hilde ;

Tiffany, Amanda ;

Dominguez, Gemma ;

Loua, Mathieu ;

Traore, Alexis ;

Kolie, Moussa ;

Malano, Emmanuel Roland ;

Heleze, Emmanuel ;

Bocquin, Anne ;

Mely, Stephane ;

Raoul, Herve ;

Caro, Valerie ;

Cadar, Daniel ;

Gabriel, Martin ;

Pahlmann, Meike ;

Tappe, Dennis ;

Schmidt-Chanasit, Jonas ;

Impouma, Benido ;

Diallo, Abdoul Karim ;

Formenty, Pierre ;

Van Herp, Michel ;

Guenther, Stephan .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (15) :1418-1425

[7] Ebolavirus VP35 Coats the Backbone of Double-Stranded RNA for Interferon Antagonism [J].

Bale, Shridhar ;

Julien, Jean-Philippe ;

Bornholdt, Zachary A. ;

Krois, Alexander S. ;

Wilson, Ian A. ;

Saphire, Erica Ollmann .

JOURNAL OF VIROLOGY, 2013, 87 (18) :10385-10388

[8] Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism [J].

Bale, Shridhar ;

Julien, Jean-Philippe ;

Bornholdt, Zachary A. ;

Kimberlin, Christopher R. ;

Halfmann, Peter ;

Zandonatti, Michelle A. ;

Kunert, John ;

Kroon, Gerard J. A. ;

Kawaoka, Yoshihiro ;

MacRae, Ian J. ;

Wilson, Ian A. ;

Saphire, Erica Ollmann .

PLOS PATHOGENS, 2012, 8 (09)

[9] The Ebola virus VP35 protein functions as a type IIFN antagonist [J].

Basler, CF ;

Wang, XY ;

Mühlberger, E ;

Volchkov, V ;

Paragas, J ;

Klenk, HD ;

Garcia-Sastre, A ;

Palese, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (22) :12289-12294

[10] The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3 [J].

Basler, CF ;

Mikulasova, A ;

Martinez-Sobrido, L ;

Paragas, J ;

Mühlberger, E ;

Bray, M ;

Klenk, HD ;

Palese, P ;

García-Sastre, A .

JOURNAL OF VIROLOGY, 2003, 77 (14) :7945-7956

← 1 2 3 4 5 6 7 8 9 10 →