Synthesis of core-shell hybrid nanoparticles with pH responsive core and silica shell and their surface characterization

被引：6

作者：

Garcia-Uriostegui, L. ^{[1
]}

Delgado, Ezequiel ^{[2
]}

Melendez-Ortiz, H., I ^{[3
]}

Toriz, Guillermo ^{[2
,4
]}

机构：

[1] Univ Guadalajara, CONACyT Dept Madera Celulosa & Papel, Km 15-5 Carretera Guadalajara Nogales, Zapopan 45110, Jalisco, Mexico

[2] Univ Guadalajara, Dept Madera Celulosa & Papel, Km 15-5 Carretera Guadalajara Nogales, Zapopan 45110, Jalisco, Mexico

[3] CONACyT Ctr Invest Quim Aplicada, Blvd Enrique Reyna Hermosillo 140, Saltillo 25294, Coahuila, Mexico

[4] Univ Guadalajara, Inst Transdiciplinar Invest & Serv, Zapopan 45150, Jalisco, Mexico

来源：

MATERIALS LETTERS | 2020年 / 280卷

关键词：

Hybrid nanoparticles; Core-shell structure; Drug delivery; Poly(vinylimidazole); Control-release; POLYMERS;

D O I：

10.1016/j.matlet.2020.128550

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Herein, the preparation of pH-sensitive core-shell hybrid nanoparticles is reported. The core, prepared by emulsion polymerization, consisted of a copolymer of polyvinylimidazole (PVIm) and 3-(trimethoxysilyl) propylmethacrylate (TMSPMA). The silica shell, obtained by sol-gel synthesis, was anchored to the core at the TMSPMA moiety via silane linking. The pH response and the size of the nanoparticles were tuned by adjusting the quantity of VIm. The shell in the particles helps to decrease the drug release around tumoral pH (6.5-7.2). (C) 2020 Elsevier B.V. All rights reserved.

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页数：5

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