Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain

被引：18

作者：

Dumitriu, Alexandra ^{[1
,2
]}

Moser, Carlee ^{[3
]}

Hadzi, Tiffany C. ^{[1
]}

Williamson, Sally L. ^{[1
]}

Pacheco, Christopher D. ^{[1
,4
]}

Hendricks, Audrey E. ^{[1
,3
]}

Latourelle, Jeanne C. ^{[1
]}

Wilk, Jemma B. ^{[1
]}

DeStefano, Anita L. ^{[1
,3
]}

Myers, Richard H. ^{[1
,2
,3
]}

机构：

[1] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02119 USA

[2] Boston Univ, Grad Program Bioinformat, Boston, MA 02215 USA

[3] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA

[4] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

来源：

PARKINSONS DISEASE | 2012年 / 2012卷

关键词：

MESSENGER-RNA EXPRESSION; GENOMEWIDE ASSOCIATION; SUBSTANTIA-NIGRA; GENE-EXPRESSION; SUSCEPTIBILITY; POLYMORPHISM; PROMOTER; MUTATION; LOCUS; AGE;

D O I：

10.1155/2012/614212

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Duplications and triplications of the alpha-synuclein (SNCA) gene increase risk for PD, suggesting increased expression levels of the gene to be associated with increased PD risk. However, past SNCA expression studies in brain tissue report inconsistent results. We examined expression of the full-length SNCA transcript (140 amino acid protein isoform), as well as total SNCA mRNA levels in 165 frontal cortex samples (101 PD, 64 control) using quantitative real-time polymerase chain reaction. Additionally, we evaluated the relationship of eight SNPs in both 5' and 3' regions of SNCA with the gene expression levels. The association between postmortem interval (PMI) and SNCA expression was different for PD and control samples: SNCA expression decreased with increasing PMI in cases, while staying relatively constant in controls. For short PMI, SNCA expression was increased in PD relative to control samples, whereas for long PMI, SNCA expression in PD was decreased relative to control samples.

引用

页数：8

共 38 条

[1]

Beach TG, 2009, ACTA NEUROPATHOL, V117, P169, DOI 10.1007/s00401-008-0450-7

[2] Alpha- and beta-synuclein expression in Parkinson disease with and without dementia [J].