The effects of 5-fluorouracil on flexor tendon healing by using a biodegradable gelatin, slow releasing system: experimental study in a hen model

被引：33

作者：

Karaaltin, M. V. ^{[1
]}

Ozalp, B. ^{[2
]}

Dadaci, M. ^{[3
]}

Kayikcioglu, A. ^{[3
]}

Kecik, A. ^{[3
]}

Oner, F. ^{[4
]}

机构：

[1] Bezmi Alem Vakif Univ, Dept Plast Reconstruct & Aesthet Surg, TR-34093 Fatih Istanbul, Turkey

[2] Istanbul Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, Istanbul, Turkey

[3] Hacettepe Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, TR-06100 Ankara, Turkey

[4] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Biotechnol, TR-06100 Ankara, Turkey

来源：

JOURNAL OF HAND SURGERY-EUROPEAN VOLUME | 2013年 / 38卷 / 06期

关键词：

5-fluorouracil; gelatin; tendon; slow releasing; adhesions; ADHESION FORMATION; INJURED TENDON; REPAIR; COLLAGEN; EXPRESSION; HYDROGELS; DELIVERY; SURFACE;

D O I：

10.1177/1753193412458646

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

This study investigated the effects of 5-fluorouracil in a slow-release biodegradable gelatin system on tendon healing. Gelatin blocks prepared in a size of 10 x 20 x 1 mm were loaded with 10, 20, and 30 mg of 5-fluorouracil, and 30 adult white Leghorn chickens were used. The tendons to the third and fourth toes were severed and repaired. The extremities were casted for three weeks. After sacrifice, the tendons were examined histologically and biomechanically for adhesion formation. The 10 mg-loaded gelatin group showed a decrease in adhesion formation when compared with the operative control group; the 20 and 30 mg groups showed signs of severe inflammation. Low doses of 5-fluorouracil applied via a slow-release gelatin system reduced adhesion formation in flexor tendon healing.

引用

页码：651 / 657

页数：7

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