Luminol-type chemiluminescence derivatization reagents for liquid chromatography and capillary electrophoresis

被引：96
作者：
Yamaguchi, M [1 ]
Yoshida, H [1 ]
Nohta, H [1 ]
机构：
[1] Fukuoka Univ, Fac Pharmaceut Sci, Fukuoka 8140180, Japan
来源：
JOURNAL OF CHROMATOGRAPHY A | 2002年 / 950卷 / 1-2期
关键词：
reviews; derivatization; LC; CE; detection; chemiluminescence detection; luminol; carbonyl compounds; hydroxyindoles; catecholamines; amines; carboxylic acids; amino acids; peptides;
D O I：
10.1016/S0021-9673(02)00004-3
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The present paper provides the principles for chemiluminescence of luminol-type compounds and their wide and powerful application to the detection system in liquid chromatography and capillary electrophoresis as derivatization reagents. The reagents can be classified into two types, chemiluminescence labeling and chemiluminogenic reagents. The former reagents are highly chemiluminescent themselves and used for tagging their intense chemiluminophores to analytes, whereas the latter are weakly chemiluminescent but generate intense chemiluminescence by reaction with analytes. The liquid chromatographic methods utilizing chemiluminescence derivatizing reactions with luminol-type reagents allow the analytes to be detected at pmol-sub-fmol levels. Furthermore, the chemiluminogenic reactions show high selectivity owing to their selective reaction against the analytes permitting facile and reproducible detection. (C) 2002 Elsevier Science B.V. All rights reserved.
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页码：1 / 19
页数：19
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