Expert consensus document from the European Society of Cardiology on catheter-based renal denervation

被引：216

作者：

Mahfoud, Felix ^{[1
]}

Luescher, Thomas Felix ^{[2
]}

Andersson, Bert ^{[3
]}

Baumgartner, Iris ^{[4
,5
]}

Cifkova, Renata ^{[6
,7
]}

DiMario, Carlo ^{[8
]}

Doevendans, Pieter ^{[9
,10
]}

Fagard, Robert ^{[11
]}

Fajadet, Jean ^{[12
]}

Komajda, Michel ^{[13
]}

LeFevre, Thierry ^{[14
]}

Lotan, Chaim ^{[15
]}

Sievert, Horst ^{[16
]}

Volpe, Massimo ^{[17
,18
]}

Widimsky, Petr ^{[19
]}

Wijns, William ^{[20
]}

Williams, Bryan ^{[21
]}

Windecker, Stephan ^{[5
,22
]}

Witkowski, Adam ^{[23
]}

Zeller, Thomas ^{[24
]}

Boehm, Michael ^{[1
]}

机构：

[1] Univ Klinikum Saarlandes, Innere Med Klin 3, Homburg, Saar, Germany

[2] Univ Zurich Hosp, Dept Cardiol, Ctr Cardiovasc, CH-8091 Zurich, Switzerland

[3] Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden

[4] Univ Bern, Swiss Cardiovasc Ctr, Bern, Switzerland

[5] Univ Hosp Bern, CH-3010 Bern, Switzerland

[6] Charles Univ Prague, Sch Med 1, Ctr Cardiovasc Prevent, Prague, Czech Republic

[7] Thomayer Hosp, Prague, Czech Republic

[8] Royal Brompton & Harefield NHS Trust, NIHR Cardiovasc BRU, London, England

[9] UMCU Utrecht Netherlands, Dept Cardiol, Utrecht, Netherlands

[10] ICIN Utrecht, Utrecht, Netherlands

[11] Katholieke Univ Leuven, Dept Cardiovasc Dis, Louvain, Belgium

[12] Clin Pasteur, Intervent Cardiol Unit, Toulouse, France

[13] Univ Paris 06, Pitie Salpetriere Hosp, Dept Cardiol, Paris, France

[14] Hop Jacques Cartier, Inst Cardiovasc Paris Sud, Massy, France

[15] Hadassah Hebrew Univ, Med Ctr, Inst Heart, Jerusalem, Israel

[16] Sankt Katharinen, CardioVasc Ctr Frankfurt, Frankfurt, Germany

[17] Univ Roma La Sapienza, Div Cardiol, Dept Clin & Mol Med, St Andrea Hosp, I-00185 Rome, Italy

[18] IRCCS Neuromed, Pozzilli, IS, Italy

[19] Charles Univ Prague, Cardioctr, Hosp Royal Vineyards, Prague, Czech Republic

[20] Cardiovasc Ctr Aalst, Aalst, Belgium

[21] UCL, Inst Cardiovasc Sci, London, England

[22] Univ Bern, Kardiol Klin, Bern, Switzerland

[23] Inst Cardiol, Dept Intervent Cardiol & Angiol, Warsaw, Poland

[24] Univ Herzzentrum Freiburg Bad Krozingen, Klin Kardiol & Angiol 2, Bad Krozingen, Germany

来源：

EUROPEAN HEART JOURNAL | 2013年 / 34卷 / 28期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/eurheartj/eht154

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Current evidence from the available clinical trials strongly support the notion that catheter-based radiofrequency ablation of renal nerves reduces blood pressure and improves blood pressure control in patients with drug-treated resistant hypertension, with data now extending out to 36 months. Accordingly, renal denervation can be considered as a therapeutic option in patients with resistant hypertension, whose blood pressure cannot be controlled by a combination of lifestyle modification and pharmacological therapy according to current guidelines. The fact that renal denervation also reduces whole-bodysympathetic nerve activity suggests that this therapy may also be beneficial in other clinical states characterized by sympathetic nervous system activation-this may ultimately lead to new indications. © The Author 2013.

引用

页码：2149 / 2157

页数：9

共 59 条

[31] Catheter-Based Renal Nerve Ablation and Centrally Generated Sympathetic Activity in Difficult-to-Control Hypertensive Patients: Prospective Case Series [J].

Mahfoud, Felix ;

Boehm, Michael ;

Rump, Lars Christian ;

Vonend, Oliver ;

Schmieder, Roland E. ;

Kintscher, Ulrich .

HYPERTENSION, 2013, 61 (02) :E17-E17

[32] Renal Hemodynamics and Renal Function After Catheter-Based Renal Sympathetic Denervation in Patients With Resistant Hypertension [J].

Mahfoud, Felix ;

Cremers, Bodo ;

Janker, Julia ;

Link, Britta ;

Vonend, Oliver ;

Ukena, Christian ;

Linz, Dominik ;

Schmieder, Roland ;

Rump, Lars Christian ;

Kindermann, Ingrid ;

Sobotka, Paul Andrew ;

Krum, Henry ;

Scheller, Bruno ;

Schlaich, Markus ;

Laufs, Ulrich ;

Boehm, Michael .

HYPERTENSION, 2012, 60 (02) :419-424

[33] Treatment Strategies for Resistant Arterial Hypertension [J].

Mahfoud, Felix ;

Himmel, Frank ;

Ukena, Christian ;

Schunkert, Heribert ;

Boehm, Michael ;

Weil, Joachim .

DEUTSCHES ARZTEBLATT INTERNATIONAL, 2011, 108 (43) :725-731

[34] Effect of Renal Sympathetic Denervation on Glucose Metabolism in Patients With Resistant Hypertension A Pilot Study [J].

Mahfoud, Felix ;

Schlaich, Markus ;

Kindermann, Ingrid ;

Ukena, Christian ;

Cremers, Bodo ;

Brandt, Mathias C. ;

Hoppe, Uta C. ;

Vonend, Oliver ;

Rump, Lars C. ;

Sobotka, Paul A. ;

Krum, Henry ;

Esler, Murray ;

Boehm, Michael .

CIRCULATION, 2011, 123 (18) :1940-1946

[35] 2007 ESH-ESC practice guidelines for the management of arterial hypertension - ESH-ESC task force on the management of arterial hypertension [J].

Mancia, Giuseppe ;

De Backer, Guy ;

Dominiczak, Anna ;

Cifkova, Renata ;

Fagarde, Robert ;

Germanof, Giuseppe ;

Grassi, Guido ;

Heagertyh, Anthony M. ;

Kjeldsen, Sverre E. ;

Laurenti, Stephanie ;

Narkiewicz, Krzysztof ;

Ruilopel, Luis ;

Rynkiewicz, Andrzej ;

Schmiedern, Roland E. ;

Boudiero, Harry A. J. Struijker ;

Zanchetti, Alberto .

JOURNAL OF HYPERTENSION, 2007, 25 (09) :1751-1762

[36] Renal sensory and sympathetic nerves reinnervate the kidney in a similar time-dependent fashion after renal denervation in rats [J].

Mulder, Jan ;

Hokfelt, Tomas ;

Knuepfer, Mark M. ;

Kopp, Ulla C. .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2013, 304 (08) :R675-R682

[37]

Ormiston J, 2012, J AM COLL CARDIOL SB, V60, pTCT

[38]

Papademetriou V, 2012, CIRCULATION, V125

[39] The human sympathetic nervous system: its relevance in hypertension and heart failure [J].

Parati, Gianfranco ;

Esler, Murray .

EUROPEAN HEART JOURNAL, 2012, 33 (09) :1058-U39

[40] Expert consensus: Renal denervation for the treatment of arterial hypertension [J].

Pathak, Atul ;

Girerd, Xavier ;

Azizi, Michel ;

Benamer, Hakim ;

Halimi, Jean-Michel ;

Lantelme, Pierre ;

Lefevre, Thierry ;

Sapoval, Marc .

ARCHIVES OF CARDIOVASCULAR DISEASES, 2012, 105 (6-7) :386-393

← 1 2 3 4 5 6 →