Morphological and functional changes in spectral domain optical coherence tomography and microperimetry in macular microhole variants: Spectral domain optical coherence tomography and microperimetry correlation

Purpose: To evaluate the relationship between the morphology and retinal function of macular microhole (MMH) variants. Materials and Methods: We evaluated 12 eyes of 11 patients with defects in the IS/OS junction of photoreceptor layer with SD-OCT. All patients underwent comprehensive ophthalmic examination including spectral domain optical coherence tomography (SD-OCT) and microperimetry. Results: The mean logMAR visual acuity in the affected eye was 0.15 +/- 0.17 (range 0.00-0.5). Mean horizontal diameter of the MMH was 163 +/- 99 mu m; the mean retinal sensitivity in the area corresponding to the MMH was 13.79 +/- 4.6 dB. Negative correlation was found between the MMH diameter and the retinal sensitivity (r = -0.65, P = 0.02). Three morphological patterns of MMH variants were recognized on SD-OCT, which did not differ in retinal sensitivities. Conclusion: We described and classified the MMH variants and made an assessment on the physiological functions using microperimeter.