Gradual tapering of desmopressin leads to better outcome in nocturnal enuresis

BackgroundAlthough desmopressin therapy is effective in treating polyuric monosymptomatic nocturnal enuresis (MNE), the relatively high rates of recurrence are problematic. To date, the treatment protocol on the discontinuation of oral desmopressin melt (ODM) tablet, MinirinMelt, has not been established. We tested two protocols of tapering ODM when the patients achieved full response on ODM, and compared the treatment outcomes. MethodsOne hundred and fifty-seven polyuric MNE children were newly treated with ODM at the authors' outpatient clinics (Juntendo Nerima Hospital and Musashi-Murayama Hospital). When the patients did not respond to the 8 week ODM therapy, we added another options such as alarm, anti-cholinergics, and imipramine (92 patients; 58.6%). Sixty-five patients (41.4%) achieved full response on ODM alone, and 49 of them accepted gradual tapering of ODM: group B (n = 25), 240g ODM per day 120g ODM per day 120g ODM per alternate day cessation; and group C (n = 24), 240g ODM per day 120g ODM per day 60g ODM per day 60g ODM per alternate day cessation. ResultsFourteen patients in group B (56%) and four in group C (17%) had relapses of enuresis after the discontinuation of ODM (P = 0.026). ConclusionsGradual tapering of ODM therapy in MNE patients leads to better outcome.