Application of ultrasound energy as a new drug delivery system

被引:66
作者
Tachibana, K
Tachibana, S
机构
[1] Fukuoka Univ, Sch Med, Dept Anat 1, Ctr Sonodynam Therapy, Fukuoka 8140180, Japan
[2] Tenjinkai New Koga Hosp, Kurume, Fukuoka 830, Japan
来源
JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS BRIEF COMMUNICATIONS & REVIEW PAPERS | 1999年 / 38卷 / 5B期
关键词
ultrasound; drug delivery system; thrombolysis; transdermal drug delivery; sonodynamic therapy; cancer;
D O I
10.1143/JJAP.38.3014
中图分类号
O59 [应用物理学];
学科分类号
摘要
Ultrasound has been in use for the last three decades as a modality for diagnostic imaging in medicine. Recently, there have been numerous reports on the application of nonthermal ultrasound energy for targeting or controlling drug release, This new concept of therapeutic ultrasound combined with drugs has led to much excitement in various medical fields. Ultrasound energy can enhance the effects of thrombolytic agents such as urokinase. Therapeutic ultrasound catheters are currently being developed for treatment of cardiovascular diseases. Devices with ultrasound transducers implanted in transdermal drug patches are also being evaluated for possible delivery of insulin through the skin. Chemical activation of drugs by ultrasound energy for treatment of cancers is another new field recently termed "Sonodynamic Therapy". Various examples of ultrasound application are under investigation which could lead to revolutionary drug delivery systems in the future.
引用
收藏
页码:3014 / 3019
页数:6
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