Two New Tirucallane-Type Triterpenoids from the Stem Barks of Aphanamixis grandifolia and Their Cytotoxic Activities

被引：13

作者：

Zhang Yao ^{[1
]}

Wang Junsong ^{[1
]}

Wang Pengran ^{[1
]}

Kong Lingyi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2012年 / 30卷 / 06期

基金：

中国国家自然科学基金;

关键词：

tirucallane; triterpenoid; cytotoxicity; Aphanamixis grandifolia; meliaceae; LIMONOID EXTRACTIVES; PROTOLIMONOIDS;

D O I：

10.1002/cjoc.201200100

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new tirucallane-type triterpenoids, 3a,24 beta,25-trihydroxy-21,21-dimethoxy-23-oxo-tirucall-7-ene (1) and 3a-acetoxy-21 beta-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone (2), were isolated from the stem barks of Aphanamixis grandifolia, and their structures were elucidated on the basis of spectroscopic data analysis including 1D, 2D NMR, IR, and ESI-MS spectral methods. The two isolates were evaluated for their cytotoxicities using NCI-H460 and HeLa cell lines.

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收藏

页码：1356 / 1360

页数：5

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