A Diagnostic Biomarker for Pediatric Generalized Anxiety Disorder Using the Error-Related Negativity

被引：16

作者：

Hanna, Gregory L. ^{[1
]}

Liu, Yanni ^{[1
]}

Rough, Haley E. ^{[1
]}

Surapaneni, Mihir ^{[1
]}

Hanna, Barbara S. ^{[1
]}

Arnold, Paul D. ^{[2
]}

Gehring, William J. ^{[3
]}

机构：

[1] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA

[2] Univ Calgary, Mathison Ctr Mental Hlth Res & Educ, Calgary, AB T2N 4N1, Canada

[3] Univ Michigan, Dept Psychol, 4250 Plymouth Rd, Ann Arbor, MI 48109 USA

来源：

CHILD PSYCHIATRY & HUMAN DEVELOPMENT | 2020年 / 51卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Anxiety; Biomarker; Diagnosis; Error-related negativity; Pediatric; Receiver operating characteristic analysis; OBSESSIVE-COMPULSIVE DISORDER; FRONTAL MIDLINE THETA; BRAIN ACTIVITY; CHILDREN; ERN; YOUTH; ADOLESCENTS; PREVALENCE; BEHAVIORS; SYSTEM;

D O I：

10.1007/s10578-020-01021-5

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

The error-related negativity (ERN) is a negative deflection in the event-related potential following a mistake that is a putative biomarker of anxiety. The study assessed the ERN as a diagnostic biomarker using receiver operating characteristic (ROC) analyses in 96 cases with anxiety disorders (AD) and 96 matched healthy controls (HC) ages 8 to 18 years. Forty-one cases had generalized anxiety disorder (GAD); 55 cases had other anxiety disorders (OAD) without GAD. ERN amplitude was significantly increased in AD cases compared to HC. The area under the curve (AUC) in the ROC analysis was 0.64, indicating the ERN is an inadequate diagnostic test for AD altogether. The ERN was significantly increased in cases with either GAD or OAD compared to HC. The AUC in ROC analyses with GAD and OAD was 0.75 and 0.56, respectively, suggesting the ERN provides an adequate diagnostic test for GAD but not for OAD.

引用

页码：827 / 838

页数：12

共 61 条

[1]

Achenbach T., 2001, MANUAL ACHENBACH SYS

[2] Multimodal neuroimaging dissociates hemodynamic and electrophysiological correlates of error processing [J].

Agam, Yigal ;

Haemaelaeinen, Matti S. ;

Lee, Adrian K. C. ;

Dyckman, Kara A. ;

Friedman, Jesse S. ;

Isom, Marlisa ;

Makris, Nikos ;

Manoach, Dara S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (42) :17556-17561

[3]

American Psychiatric Association, 2013, DIAGNOSTIC STAT MANU, V5, DOI 10.1176/appi.books.9780890425596

[4] Heritability of frontal brain function related to action monitoring [J].

Anokhin, Andrey P. ;

Golosheykin, Simon ;

Heath, Andrew C. .

PSYCHOPHYSIOLOGY, 2008, 45 (04) :524-534

[5] Strategic control and medial frontal negativity: Beyond errors and response conflict [J].

Bartholow, BD ;

Pearson, MA ;

Dickter, CL ;

Sher, KJ ;

Fabiani, M ;

Gratton, G .

PSYCHOPHYSIOLOGY, 2005, 42 (01) :33-42

[6] Anxiety disorders and suicidal behaviours in adolescence and young adulthood: findings from a longitudinal study [J].

Boden, Joseph M. ;

Fergusson, David M. ;

Horwood, L. John .

PSYCHOLOGICAL MEDICINE, 2007, 37 (03) :431-440

[7] Toddler Fearfulness Is Linked to Individual Differences in Error-Related Negativity During Preschool [J].

Brooker, Rebecca J. ;

Buss, Kristin A. .

DEVELOPMENTAL NEUROPSYCHOLOGY, 2014, 39 (01) :1-8

[8] Development of the error-monitoring system from ages 9-35: Unique insight provided by MRI-constrained source localization of EEG [J].

Buzzell, George A. ;

Richards, John E. ;

White, Lauren K. ;

Barker, Tyson V. ;

Pine, Daniel S. ;

Fox, Nathan A. .

NEUROIMAGE, 2017, 157 :13-26

[9] ERN, theta power, and risk for anxiety problems in preschoolers [J].

Canen, Mara J. ;

Brooker, Rebecca J. .

BIOLOGICAL PSYCHOLOGY, 2017, 123 :103-110

[10] Increased error-related brain activity in youth with obsessive-compulsive disorder and other anxiety disorders [J].

Carrasco, Melisa ;

Hong, Christina ;

Nienhuis, Jenna K. ;

Harbin, Shannon M. ;

Fitzgerald, Kate D. ;

Gehring, William J. ;

Hanna, Gregory L. .

NEUROSCIENCE LETTERS, 2013, 541 :214-218

← 1 2 3 4 5 6 7 →