Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence

被引：103

作者：

Wang, Qiao ^{[1
]}

Peng, Hongling ^{[1
]}

Qi, Xiaorong ^{[1
]}

Wu, Min ^{[2
]}

Zhao, Xia ^{[1
]}

机构：

[1] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Child, West China Hosp 2,Dept Gynecol & Obstet,Minist Ed, Dev & Related Dis Women & Children Key Lab Sichua, Chengdu 610041, Sichuan, Peoples R China

[2] Univ North Dakota, Sch Med & Hlth Sci, Dept Biomed Sci, Grand Forks, ND 58203 USA

来源：

SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2020年 / 5卷 / 01期

关键词：

PHASE-II TRIAL; RECURRENT EPITHELIAL OVARIAN; PLATINUM-RESISTANT OVARIAN; PRIMARY PERITONEAL CARCINOMA; ANTIBODY-DRUG CONJUGATE; POLY(ADP-RIBOSE) POLYMERASE INHIBITOR; PERSISTENT ENDOMETRIAL CANCER; MIRVETUXIMAB SORAVTANSINE IMGN853; PEGYLATED LIPOSOMAL DOXORUBICIN; SQUAMOUS-CELL-CARCINOMA;

D O I：

10.1038/s41392-020-0199-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Advanced and recurrent gynecological cancers are associated with poor prognosis and lack of effective treatment. The developments of the molecular mechanisms on cancer progression provide insight into novel targeted therapies, which are emerging as groundbreaking and promising cancer treatment strategies. In gynecologic malignancies, potential therapeutic targeted agents include antiangiogenic agents, poly (ADP-ribose) polymerase (PARP) inhibitors, tumor-intrinsic signaling pathway inhibitors, selective estrogen receptor downregulators, and immune checkpoint inhibitors. In this article, we provide a comprehensive review of the clinical evidence of targeted agents in gynecological cancers and discuss the future implication.

引用

页数：34

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