Advance in Drug Delivery for Ageing Skeletal Muscle

被引：11

作者：

Li, Yi ^{[1
,2
]}

Chen, Ming ^{[1
,2
]}

Zhao, Yanpeng ^{[1
,2
]}

Li, Ming ^{[1
,2
]}

Qin, Yong ^{[3
]}

Cheng, Shi ^{[3
]}

Yang, Yanyu ^{[4
]}

Yin, Pengbin ^{[1
,2
]}

Zhang, Licheng ^{[1
,2
]}

Tang, Peifu ^{[1
,2
]}

机构：

[1] Gen Hosp Chinese PLA, Dept Orthoped, Beijing, Peoples R China

[2] Natl Clin Res Ctr Orthoped Sports Med & Rehabil, Beijing, Peoples R China

[3] Harbin Med Univ, Dept Orthoped Surg, Affiliated Hosp 2, Harbin, Peoples R China

[4] Zhengzhou Univ, Coll Mat Sci & Engn, Zhengzhou, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2020年 / 11卷

基金：

中国国家自然科学基金;

关键词：

ageing skeletal muscle; drug delivery; extracellular vesicle; sarcopenia; skeletal muscle regeneration; MYOSTATIN ANTIBODY LY2495655; STEM-CELLS; EXTRACELLULAR VESICLES; SATELLITE CELLS; REGENERATION; EFFICACY; PLACEBO; SAFETY; DIFFERENTIATION; NANOPARTICLES;

D O I：

10.3389/fphar.2020.01016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The age-related loss of skeletal muscle, sarcopenia, is characterized by progressive loss of muscle mass, reduction in muscle strength, and dysfunction of physical performance. It has become a global health problem leading to several adverse outcomes in the ageing population. Research on skeletal muscle loss prevention and treatment is developing quickly. However, the current clinical approaches to sarcopenia are limited. Recently, novel drug delivery systems offer new possibilities for treating aged muscle loss. Herein, we briefly recapitulate the potential therapeutic targets of aged skeletal muscle and provide a concise advance in the drug delivery systems, mainly focus on the use of nano-carriers. Furthermore, we elaborately discuss the prospect of aged skeletal muscle treatment by nanotechnology approaches.

引用

页数：9

共 88 条

[21] Aging, metabolism and stem cells: Spotlight on muscle stem cells [J].

Garcia-Prat, Laura ;

Munoz-Canoves, Pura .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2017, 445 (0C) :109-117

[22] Autophagy maintains stemness by preventing senescence [J].

Garcia-Prat, Laura ;

Martinez-Vicente, Marta ;

Perdiguero, Eusebio ;

Ortet, Laura ;

Rodriguez-Ubreva, Javier ;

Rebollo, Elena ;

Ruiz-Bonilla, Vanessa ;

Gutarra, Susana ;

Ballestar, Esteban ;

Serrano, Antonio L. ;

Sandri, Marco ;

Munoz-Canoves, Pura .

NATURE, 2016, 529 (7584) :37-+

[23] Gold and gold-silver alloy nanoparticles enhance the myogenic differentiation of myoblasts through p38 MAPK signaling pathway and promote in vivo skeletal muscle regeneration [J].

Ge, Juan ;

Liu, Kai ;

Niu, Wen ;

Chen, Mi ;

Wang, Min ;

Xue, Yumeng ;

Gao, Chuanbo ;

Ma, Peter X. ;

Lei, Bo .

BIOMATERIALS, 2018, 175 :19-29

[24] Mutation inmyostatin 3'UTR promotes C2C12 myoblast proliferation and differentiation by blocking the translation of MSTN [J].

Ge, Luxing ;

Dong, Xiangchen ;

Gong, Xutong ;

Kang, Jian ;

Zhang, Yong ;

Quan, Fusheng .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 154 :634-643

[25] Advances in therapy for spinal muscular atrophy: promises and challenges [J].

Groen, Ewout J. N. ;

Talbot, Kevin ;

Gillingwater, Thomas H. .

NATURE REVIEWS NEUROLOGY, 2018, 14 (04) :214-224

[26] Muscle Releases Alpha-Sarcoglycan Positive Extracellular Vesicles Carrying miRNAs in the Bloodstream [J].

Guescini, Michele ;

Canonico, Barbara ;

Lucertini, Francesco ;

Maggio, Serena ;

Annibalini, Giosue ;

Barbieri, Elena ;

Luchetti, Francesca ;

Papa, Stefano ;

Stocchi, Vilberto .

PLOS ONE, 2015, 10 (05)

[27] Muscle weakness and selective muscle atrophy in osteoprotegerin-deficient mice [J].

Hamoudi, Dounia ;

Bouredji, Zineb ;

Marcadet, Laetitia ;

Yagita, Hideo ;

Landry, Louis-Benedict ;

Argaw, Anteneh ;

Frenette, Jerome .

HUMAN MOLECULAR GENETICS, 2020, 29 (03) :483-494

[28] Safety and efficacy of intravenous bimagrumab in inclusion body myositis (RESILIENT): a randomised, double-blind, placebo-controlled phase 2b trial [J].

Hanna, Michael G. ;

Badrising, Umesh A. ;

Benveniste, Olivier ;

Lloyd, Thomas E. ;

Needham, Merrilee ;

Chinoy, Hector ;

Aoki, Masashi ;

Machado, Pedro M. ;

Liang, Christina ;

Reardon, Katrina A. ;

de Visser, Marianne ;

Ascherman, Dana P. ;

Barohn, Richard J. ;

Dimachkie, Mazen M. ;

Miller, James A. L. ;

Kissel, John T. ;

Oskarsson, Bjoern ;

Joyce, Nanette C. ;

Van den Bergh, Peter ;

Baets, Jonathan ;

De Bleecker, Jan L. ;

Karam, Chafic ;

David, William S. ;

Mirabella, Massimiliano ;

Nations, Sharon P. ;

Jung, Hans H. ;

Pegoraro, Elena ;

Maggi, Lorenzo ;

Rodolico, Carmelo ;

Filosto, Massimiliano ;

Shaibani, Aziz, I ;

Sivakumar, Kumaraswamy ;

Goyal, Namita A. ;

Mori-Yoshimura, Madoka ;

Yamashita, Satoshi ;

Suzuki, Naoki ;

Katsuno, Masahisa ;

Murata, Kenya ;

Nodera, Hiroyuki ;

Romano, Carla D. ;

Williams, Valerie S. L. ;

Vissing, John ;

Auberson, Lixin Zhang ;

Wu, Min ;

de Vera, Ana ;

Papanicolaou, Dimitris A. ;

Amato, Anthony A. ;

Nishino, Ichizo .

LANCET NEUROLOGY, 2019, 18 (09) :834-844

[29] Current pharmacotherapies for sarcopenia [J].

Hardee, Justin P. ;

Lynch, Gordon S. .

EXPERT OPINION ON PHARMACOTHERAPY, 2019, 20 (13) :1645-1657

[30] Sclerostin inhibition alleviates breast cancer-induced bone metastases and muscle weakness [J].

Hesse, Eric ;

Schroeder, Saskia ;

Brandt, Diana ;

Pamperin, Jenny ;

Saito, Hiroaki ;

Taipaleenmaeki, Hanna .

JCI INSIGHT, 2019, 4 (09)

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