Clinicopathological Characteristics of Young Patients With Pancreatic Cancer: An Analysis of Data From Pancreatic Cancer Registry of Japan Pancreas Society

被引：25

作者：

Eguchi, Hidetoshi ^{[1
,2
]}

Yamaue, Hiroki ^{[1
,3
]}

Unno, Michiaki ^{[1
,4
]}

Mizuma, Masamichi ^{[1
,4
]}

Hamada, Shin ^{[1
,5
]}

Igarashi, Hisato ^{[1
,6
]}

Kuroki, Tamotsu ^{[1
,7
]}

Satoi, Sohei ^{[1
,8
]}

Shimizu, Yasuhiro ^{[1
,9
]}

Tani, Masaji ^{[1
,10
]}

Tanno, Satoshi ^{[1
,11
]}

Hirooka, Yoshiki ^{[1
,12
]}

Fujii, Tsutomu ^{[1
,13
]}

Masamune, Atsushi ^{[1
,5
]}

Mizumoto, Kazuhiro ^{[1
,14
]}

Itoi, Takao ^{[1
,15
]}

Egawa, Shinichi ^{[1
,4
]}

Kodama, Yuzo ^{[1
,16
]}

Tanaka, Masao ^{[1
,17
]}

Shimosegawa, Tooru ^{[1
,5
]}

机构：

[1] Japan Pancreas Soc, Sendai, Miyagi, Japan

[2] Osaka Univ, Grad Sch Med, Dept Surg, 2-2 Yamadaoka E-2, Suita, Osaka 5650871, Japan

[3] Wakayama Med Univ, Dept Surg 2, Wakayama, Japan

[4] Tohoku Univ, Grad Sch Med, Dept Surg, Sendai, Miyagi, Japan

[5] Tohoku Univ, Grad Sch Med, Div Gastroenterol, Sendai, Miyagi, Japan

[6] Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka, Japan

[7] Nagasaki Univ, Grad Sch Biomed Sci, Dept Surg, Nagasaki, Japan

[8] Kansai Med Univ, Dept Surg, Osaka, Japan

[9] Aichi Canc Ctr Hosp, Dept Surg Gastroenterol, Nagoya, Aichi, Japan

[10] Shiga Univ Med Sci, Dept Surg, Otsu, Shiga, Japan

[11] IMS Sapporo Digest Ctr Gen Hosp, Dept Gastroenterol, Sapporo, Hokkaido, Japan

[12] Nagoya Univ Hosp, Dept Endoscopy, Nagoya, Aichi, Japan

[13] Nagoya Univ, Grad Sch Med, Dept Gastroenterol Surg Surg 2, Nagoya, Aichi, Japan

[14] Kyushu Univ Hosp, Ctr Canc, Fukuoka, Japan

[15] Tokyo Med Univ, Dept Gastroenterol & Hepatol, Tokyo, Japan

[16] Kyoto Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Kyoto, Japan

[17] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Oncol, Fukuoka, Japan

来源：

PANCREAS | 2016年 / 45卷 / 10期

关键词：

pancreatic ductal adenocarcinoma; early-onset pancreatic cancer; familial pancreatic cancer; young patients; ADENOCARCINOMA;

D O I：

10.1097/MPA.0000000000000636

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives The aim of this study was to determine the characteristics of patients with pancreatic ductal adenocarcinoma younger than 40 years. Methods Data from the Japan Pancreas Society's nationwide Pancreatic Cancer Registry were analyzed retrospectively. Clinicopathological characteristics were compared in patients who were grouped according to age, namely, younger than 40 years versus 40 years and older. Results Of the 36 145 patients in the database, the younger group included 526 (1.5%) patients. A family history of pancreatic cancer was not more frequent in the younger group. The frequency of Union Internationale Contre le Cancer T4 and M1 were both significantly higher in younger patients, resulting in a higher percentage of patients with Union Internationale Contre le Cancer stage IV. Pancreatectomy was performed less frequently in the younger group, and R0 resection was also less frequent. The overall survival rate was significantly better in the older group, whereas in surgically resected patients, the overall survival and recurrence-free survival rates were not different between the 2 groups. Conclusions Younger patients with pancreatic adenocarcinoma were more often diagnosed at advanced stages, and the overall survival rate was worse than that in older patients. Family genetic background and the prognoses of patients who underwent surgery were similar between the 2 groups.

引用

页码：1411 / 1417

页数：7

共 15 条

[1]

[Anonymous], CANC STAT GRAPH DAT

[2] Molecular characterisation of pancreatic ductal adenocarcinoma in patients under 40 [J].