Nrf2-Mediated Metabolic Reprogramming in Cancer

被引：53
作者：
Wang, Yan-Yang [1 ,2 ]
Chen, Juan [3 ]
Liu, Xiao-Ming [4 ]
Zhao, Ren [1 ,2 ]
Zhe, Hong [1 ,2 ]
机构：
[1] Ningxia Med Univ, Dept Radiat Oncol, Gen Hosp, Ningxia 750004, Peoples R China
[2] Ningxia Med Univ, Canc Inst, Ningxia 750004, Peoples R China
[3] Ningxia Med Univ, Dept Pulm & Crit Care Med, Gen Hosp, Ningxia 750004, Peoples R China
[4] Ningxia Med Univ, Human Stem Cell Inst, Gen Hosp, Ningxia 750004, Peoples R China
来源：
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2018年 / 2018卷
基金：
中国国家自然科学基金;
关键词：
TRANSCRIPTION FACTOR NRF2; PROTEIN-KINASE-C; KEAP1-NRF2; PATHWAY; AUTOPHAGY; CELLS; PHOSPHORYLATION; ACTIVATION; P62; GLUCOSE-6-PHOSPHATE-DEHYDROGENASE; DEGRADATION;
D O I：
10.1155/2018/9304091
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Metabolic reprogramming is one of the hallmarks of cancer. Nrf2 pathway is one of the critical signaling cascades involved in cell defense and survival against oxidative stress. The significance of Nrf2 in cancer metabolism begins to be recognized. In this minireview, we focus on the Nrf2-mediated cancer metabolic reprogramming and intend to highlight the role of Nrf2 in the regulation of malignant transformation, cancer proliferation, and the development of treatment resistance via metabolic adaptations. We hope for the development of noninvasive biomarkers and novel therapeutic approaches for cancer based on Nrf2-directed cancer metabolic reprogramming in the near future.
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页数：7
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