Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression

被引：22

作者：

Zhang, Sheng ^{[1
]}

Li, Jie ^{[1
]}

Liu, Pingguo ^{[1
]}

Xu, Jianfeng ^{[1
]}

Zhao, Wenxiu ^{[1
]}

Xie, Chengrong ^{[1
]}

Yin, Zhenyu ^{[1
]}

Wang, Xiaomin ^{[1
]}

机构：

[1] Xiamen Univ, ZhongShan Hosp, Fujian Prov Key Lab Chron Liver Dis & Hepatocellu, Dept Hepatobiliary Surg, Xiamen, Fujian, Peoples R China

来源：

ONCOTARGET | 2015年 / 6卷 / 13期

基金：

中国国家自然科学基金;

关键词：

pygopus-2; E-cadherin; hepatic carcinoma; invasion; metastasis; STEM-CELLS; WNT; CANCER; CATENIN; PATHWAY; TARGET; MICE; ZEB;

D O I：

10.18632/oncotarget.3570

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pygopus-2 over-expression has been reported in several malignancies, such as ovarian, breast, lung and liver cancers. Here we demonstrated that down-regulation of Pygopus-2 by shRNA inhibited hepatic carcinoma cell invasion in vitro and metastasis in xenograft tumor models, which were promoted when Pygopus-2 was overexpressed. Pygopus-2 increased hepatic carcinoma cell invasion and metastasis, by decreasing E-cadherin. Pygopus-2 could bind to the E-cadherin promoter, increasing its methylation, and also indirectly decreased zeb2 expression. In turn these effects caused down-regulation of E-cadherin, potentiating invasion and metastasis. We suggest that targeting Pygopus-2 may potentially inhibit metastasis of hepatic carcinoma.

引用

页码：11074 / 11086

页数：13

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