Association of Reelin gene polymorphisms with autism

被引：81

作者：

Serajee, FJ

Zhong, HL

Huq, AHMM ^{[1
]}

机构：

[1] Wayne State Univ, Dept Pediat, Detroit, MI 48201 USA

[2] Wayne State Univ, Dept Neurol, Detroit, MI 48201 USA

来源：

GENOMICS | 2006年 / 87卷 / 01期

关键词：

Reelin; autism;

D O I：

10.1016/j.ygeno.2005.09.008

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Genome scans indicate a linkage of autism to the chromosome 7q21-q36 region. Recent studies suggest that the Reelin gene may be one of the loci contributing to the positive linkage between chromosome 7q and autism. However, these studies were relatively small scale, using a few markers in the gene. We investigated 34 single nucleotide polymorphisms (SNPs) in the Reelin gene with an average spacing between the SNPs of 15 kb for evidence of association with autism. There were significant differences in the transmission of the alleles of exon 22 and intron 59 SNP to autistic subjects. Our findings support a role for the Reelin gene in the susceptibility to autism. (c) 2005 Elsevier Inc. All rights reserved.

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页码：75 / 83

页数：9

相关论文

共 52 条

[11] A general and accurate approach for computing the statistical power of the transmission disequilibrium test for complex disease genes [J].

Chen, WM ;

Deng, HW .

GENETIC EPIDEMIOLOGY, 2001, 21 (01) :53-67

[12] Alleles of a Reelin CGG repeat do not convey liability to autism in a sample from the CPEA network [J].

Devlin, B ;

Bennett, P ;

Dawson, G ;

Figlewicz, DA ;

Grigorenko, EL ;

McMahon, W ;

Minshew, N ;

Pauls, D ;

Smith, M ;

Spence, MA ;

Rodier, PM ;

Stodgell, C ;

Schellenberg, GD .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2004, 126B (01) :46-50

[13] Unbiased application of the transmission/disequilibrium test to multilocus haplotypes [J].

Dudbridge, F ;

Koeleman, BPC ;

Todd, JA ;

Clayton, DG .

AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 66 (06) :2009-2012

[14] Pedigree disequilibrium tests for multilocus haplotypes [J].

Dudbridge, F .

GENETIC EPIDEMIOLOGY, 2003, 25 (02) :115-121

[15] SNP association studies in Alzheimer's disease highlight problems for complex disease analysis [J].

Emahazion, T ;

Feuk, L ;

Jobs, M ;

Sawyer, SL ;

Fredman, D ;

St Clair, D ;

Prince, JA ;

Brookes, AJ .

TRENDS IN GENETICS, 2001, 17 (07) :407-413

[16] Reduced blood levels of reelin as a vulnerability factor in pathophysiology of autistic disorder [J].

Fatemi, SH ;

Stary, JM ;

Egan, EA .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 2002, 22 (02) :139-152

[17] Dysregulation of Reelin and Bcl-2 proteins in autistic cerebellum [J].

Fatemi, SH ;

Stary, JM ;

Halt, AR ;

Realmuto, GR .

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2001, 31 (06) :529-535

[18] Reelin mutations in mouse and man: from reeler mouse to schizophrenia, mood disorders, autism and lissencephaly [J].

Fatemi, SH .

MOLECULAR PSYCHIATRY, 2001, 6 (02) :129-133

[19] Altered levels of Reelin and its isoforms in schizophrenia and mood disorders [J].

Fatemi, SH ;

Kroll, JL ;

Stary, JM .

NEUROREPORT, 2001, 12 (15) :3209-3215

[20]

FOLSTEIN SE, 1991, PEDIATRICS, V87, P767

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