Towards synthetic viruses

被引：189

作者：

Zuber, G ^{[1
]}

Dauty, E

Nothisen, M

Belguise, P

Behr, JP

机构：

[1] CNRS, Lab Chim Genet, F-67401 Illkirch Graffenstaden, France

[2] Univ Louis Pasteur Strasbourg 1, Fac Pharm, F-67401 Illkirch Graffenstaden, France

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2001年 / 52卷 / 03期

关键词：

artificial virus; gene delivery; synthetic multicomponent vectors;

D O I：

10.1016/S0169-409X(01)00213-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gene delivery is too complex to be performed with a single carrier molecule. Synthetic multicomponent vectors are being designed that mimic key properties of viruses. Some solutions, such as diverting cell-anchoring molecules or the endogenous nuclear import machinery from their normal function, are directly copied from bacteria and viruses. Some other solutions are original ones; monomolecular genome condensation via detergent dimerization or endosome disruption by the proton sponge effect are not exploited by natural cell invaders. All these components, however, still have to be assembled into a unique supramolecular system, an 'artificial virus'. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：245 / 253

页数：9

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