Ras family of small GTPases in immunity and inflammation

被引：98

作者：

Johnson, Derek S. ^{[1
]}

Chen, Youhai H. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2012年 / 12卷 / 04期

基金：

美国国家卫生研究院;

关键词：

T-CELL-ACTIVATION; INTEGRIN ACTIVATION; MAMMALIAN TARGET; PHOSPHOLIPASE-D; RAP1; RAPAMYCIN; MIGRATION; ADHESION; DISTINCT; KINASE;

D O I：

10.1016/j.coph.2012.02.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The Ras superfamily of small GTPases is a group of more than 150 small G proteins, all of which share some degree of homology to the founding member Ras. These small GTPases function as molecular switches within cells, impacting nearly all cellular processes. The Ras superfamily can be further divided into several smaller subfamilies, with those proteins that most closely resemble Ras belonging to the Ras subfamily. While heavily studied within the field of cancer biology, the Ras family of proteins also plays cardinal roles in immunity and inflammation. Here we review the roles of these molecular switches in regulating immune cell homeostasis and functions.

引用

页码：458 / 463

页数：6

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