Phytochelatins inhibit the metal-induced aggregation of α-crystallin

被引：3

作者：

Hori, Yasuhisa ^{[1
]}

Yoshikawa, Tomoaki ^{[2
]}

Tsuji, Naoki ^{[1
]}

Bamba, Takeshi ^{[3
]}

Aso, Yoshikazu ^{[4
]}

Kudou, Motonori ^{[4
]}

Uchida, Yoshiki ^{[5
]}

Takagi, Masahiro ^{[4
]}

Harada, Kazuo ^{[1
]}

Hirata, Kazumasa ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Dept Environm Biotechnol, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Sch Pharmaceut Sci, Ctr Adv Res & Educ Drug Discovery & Dev, Suita, Osaka 5650871, Japan

[3] Osaka Univ, Grad Sch Engn, Dept Biotechnol, Suita, Osaka 5650871, Japan

[4] Japan Adv Inst Sci & Technol, Sch Mat Sci, Tatsunokuchi, Ishikawa 9231292, Japan

[5] Osaka Shoin Womens Univ, Dept Food Sci & Nutr, Osaka 5778550, Japan

来源：

JOURNAL OF BIOSCIENCE AND BIOENGINEERING | 2009年 / 107卷 / 02期

关键词：

Phytochelatins; Conformational disease; Cataracts; alpha-Crystallin; Heavy metal; AGE-RELATED CATARACT; AMYLOID FORMATION; OXIDATIVE STRESS; AQUEOUS-HUMOR; HEAVY-METALS; ZINC; DISEASES; LENS;

D O I：

10.1016/j.jbiosc.2008.09.021

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Phytochelatins (PCs) are heavy-metal-binding peptides found in some eukaryotes. This study investigates the use of plant-derived PCs for the inhibition of metal-induced protein aggregation. The results of this study show that PCs inhibit zinc-induced alpha-crystallin aggregation, and suggest that PCs might be useful as anti-cataract agents. (C) 2008, The Society for Biotechnology, Japan. All rights reserved.

引用

页码：173 / 176

页数：4

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