Systematic evolution of a porous hydroxyapatite-poly(vinylalcohol)-gelatin composite

被引:30
作者
Nayar, S [1 ]
Sinha, A [1 ]
机构
[1] Natl Met Lab, Mat Sci & Technol Div, Jamshedpur 831007, Bihar, India
关键词
biomimetic-synthesis; poly(vinylalcohol); gelatin; hydroxyapatite;
D O I
10.1016/j.colsurfb.2004.01.013
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Hydroxyapatite (HAp)-poly(vinylalcohol) (PVA)-gelatin nanocomposite was biomimetically synthesized and characterized. Fourier transform infrared spectroscopy (FT-IR) analysis of hydroxyapatite, hydroxyapatite-poly(vinylalcohol) and hydroxyapatite-poly(vinylalcohol)gelatin composites show modification of hydroxyl, amide and phosphate bands as a result of chemical interaction of hydroxyapatite with the above composite matrices. Transmission electron microscopy (TEM) confirmed the time-dependent development of a porous structure of hydroxyapatite-poly(vinylalcohol)-gelatin as a consequence of nucleation at the HAp aggregate-matrix interface. A literature survey holds great promise for the above as scaffolds in terms of increased mechanical properties and bioactivity. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:29 / 32
页数:4
相关论文
共 23 条
[1]   Will biomimetics provide new answers for old problems of calcified tissues? [J].
Boskey, AL .
CALCIFIED TISSUE INTERNATIONAL, 1998, 63 (03) :179-182
[2]   Preparation of hydroxyapatite-gelatin nanocomposite [J].
Chang, MC ;
Ko, CC ;
Douglas, WH .
BIOMATERIALS, 2003, 24 (17) :2853-2862
[3]   FT-IR study for hydroxyapatite/collagen nanocomposite cross-linked by glutaraldehyde [J].
Chang, MC ;
Tanaka, J .
BIOMATERIALS, 2002, 23 (24) :4811-4818
[4]   XPS study for the microstructure development of hydroxyapatite-collagen nanocomposites cross-linked using glutaraldehyde [J].
Chang, MC ;
Tanaka, J .
BIOMATERIALS, 2002, 23 (18) :3879-3885
[5]   Preparation of a porous hydroxyapatite/collagen nanocomposite using glutaraldehyde as a crosslinkage agent [J].
Chang, MC ;
Ikoma, T ;
Kikuchi, M ;
Tanaka, J .
JOURNAL OF MATERIALS SCIENCE LETTERS, 2001, 20 (13) :1199-1201
[6]   GLUTARALDEHYDE AS A CROSS-LINKING AGENT FOR COLLAGEN-BASED BIOMATERIALS [J].
DAMINK, LHHO ;
DIJKSTRA, PJ ;
VANLUYN, MJA ;
VANWACHEM, PB ;
NIEUWENHUIS, P ;
FEIJEN, J .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1995, 6 (08) :460-472
[7]   HYDROGELS OF POLY(VINYL ALCOHOL) AND COLLAGEN AS NEW BIOARTIFICIAL MATERIALS .1. PHYSICAL AND MORPHOLOGICAL CHARACTERIZATION [J].
GIUSTI, P ;
LAZZERI, L ;
BARBANI, N ;
NARDUCCI, P ;
BONARETTI, A ;
PALLA, M ;
LELLI, L .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1993, 4 (06) :538-542
[8]   Self-organization mechanism in a bone-like hydroxyapatite/collagen nanocomposite synthesized in vitro and its biological reaction in vivo [J].
Kikuchi, M ;
Itoh, S ;
Ichinose, S ;
Shinomiya, K ;
Tanaka, J .
BIOMATERIALS, 2001, 22 (13) :1705-1711
[9]   Fibrillogenesis of hydroxyapatite/collagen self-organized composites [J].
Kikuchi, M ;
Itoh, S ;
Matsumoto, HN ;
Koyama, Y ;
Takakuda, K ;
Shinomiya, K ;
Tanaka, J .
BIOCERAMICS 15, 2003, 240-2 :567-570
[10]   Cross-linkage of hydroxyapatite/collagen nano-composite with 3 different reagents [J].
Kikuchi, M ;
Taguchi, T ;
Matsumoto, HN ;
Takakuda, K ;
Tanaka, J .
BIOCERAMICS 14, 2002, 218-2 :449-452