WT1 isoform expression pattern in acute myeloid leukemia

被引：14

作者：

Luna, Irene ^{[1
]}

Such, Esperanza ^{[1
]}

Cervera, Jose ^{[1
]}

Barragan, Eva ^{[2
]}

Ibanez, Mariam ^{[1
]}

Gomez-Segui, Ines ^{[1
]}

Lopez-Pavia, Maria ^{[1
]}

Llop, Marta ^{[2
]}

Fuster, Oscar ^{[2
]}

Dolz, Sandra ^{[2
]}

Oltra, Silvestre ^{[3
]}

Alonso, Carmen ^{[1
]}

Vera, Belen ^{[1
]}

Lorenzo, Ignacio ^{[1
]}

Martinez-Cuadron, David ^{[1
]}

Montesinos, Pau ^{[1
]}

Leonor Senent, M. ^{[1
]}

Moscardo, Federico ^{[1
]}

Bolufer, Pascual ^{[2
]}

Sanz, Miguel A. ^{[1
,4
]}

机构：

[1] Hosp Univ & Politecn La Fe, Dept Hematol, Valencia, Spain

[2] Hosp Univ La Fe, Dept Med Pathol, Mol Biol Lab, Valencia 46009, Spain

[3] Hosp Univ La Fe, Genet Unit, Valencia 46009, Spain

[4] Univ Valencia, Fac Med, E-46003 Valencia, Spain

来源：

LEUKEMIA RESEARCH | 2013年 / 37卷 / 12期

关键词：

Acute myeloid leukemia; WT1; isoforms; WILMS-TUMOR GENE; MINIMAL RESIDUAL DISEASE; PROGNOSTIC-FACTOR; GROUP-B; MUTATIONS; RNA; CONSEQUENCES; CHEMOTHERAPY; DISRUPTION; APOPTOSIS;

D O I：

10.1016/j.leukres.2013.10.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

WT1 plays a dual role in leukemia development, probably due to an imbalance in the expression of the 4 main WT1 isoforms. We quantify their expression and evaluate them in a series of AML patients. Our data showed a predominant expression of isoform Din AML, although in a lower quantity than in normal CD34+ cells. We found a positive correlation between the total WT1 expression and A, B and C isoforms. The overexpression of WT1 in AML might be due to a relative increase in A, B and C isoforms, together with a relative decrease in isoform D expression. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1744 / 1749

页数：6

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