An obesity genetic risk score is associated with metabolic syndrome in Chinese children

被引：41

作者：

Zhao, Xiaoyuan ^{[1
]}

Xi, Bo ^{[2
]}

Shen, Yue ^{[1
]}

Wu, Lijun ^{[1
]}

Hou, Dongqing ^{[1
]}

Cheng, Hong ^{[1
]}

Mi, Jie ^{[1
]}

机构：

[1] Capital Inst Pediat, Dept Epidemiol, Beijing 100020, Peoples R China

[2] Shandong Univ, Sch Publ Hlth, Dept Maternal & Child Hlth Care, Jinan 250012, Peoples R China

来源：

GENE | 2014年 / 535卷 / 02期

基金：

高等学校博士学科点专项科研基金;

关键词：

Metabolic syndrome; Obesity; Polymorphism; Children; Chinese; BODY-MASS INDEX; GENOME-WIDE ASSOCIATION; COMMON VARIANTS; ADULT OBESITY; FAT MASS; FTO GENE; LOCI; ADOLESCENTS; POPULATIONS; PREVALENCE;

D O I：

10.1016/j.gene.2013.11.006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) associated with body mass index (BMI)/obesity. In this study, we aim to examine the associations of obesity related loci with risk of metabolic syndrome (MetS) in a children population from China. A total of 431 children with MetS and 3046 controls were identified based on the modified ATPIII definition. 11 SNPs (FTO rs9939609, MC4R rs17782313, GNPDA2 rs10938397, BDNF rs6265, FAIM2 rs7138803, NPC1 rs1805081, SEC16B rs10913469, SH2B1 rs4788102, PCSK1rs6235, KCTD15 rs29941, BAT2 rs2844479) were genotyped by TaqMan 7900. Of 11 SNPs, GNPDA2 rs10938397, BDNF rs6265, and FAIM2 rs7138803 were nominally associated with risk of MetS (GNPDA2 rs10938397: odds ratio (OR) = 1.21, 95% confidence interval (CI) = 1.04-1.40, P = 0.016; BDNF rs6265: OR = 1.19, 95% CI = 1.03-1.39, P = 0.021; FAIM2 rs7138803: OR = 1.20, 95% CI = 1.02-1.40, P = 0.025); genetic risk score (GRS) was significantly associated with risk of MetS (OR = 1.09, 95% CI = 1.04-1.15, P = 5.26 x 10(-4)). After further adjustment for BMI, none of SNPs were associated with risk of MetS (all P > 0.05); the association between GRS and risk of MetS remained nominally (OR = 1.02, 95%CI = 0.96-1.08, P = 0.557). However, after correction for multiple testing, only GRS was statistically associated with risk of MetS in the model without adjustment for BMI. The present study demonstrated that there were nominal associations of GNPDA2 rs10938397, BDNF rs6265, and FAIM2 rs7138803 with risk of MetS. The SNPs in combination have a significant effect on risk of MetS among Chinese children. These associations above were mediated by adiposity. (C) 2013 Elsevier B.V. All tights reserved.

引用

页码：299 / 302

页数：4

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