Coronavirus in Continuous Flux: From SARS-CoV to SARS-CoV-2

被引：15

作者：

Dong, Yetian ^{[1
,2
,3
,4
]}

Dai, Tong ^{[1
,2
]}

Liu, Jun ^{[5
]}

Zhang, Long ^{[3
,4
]}

Zhou, Fangfang ^{[1
,2
]}

机构：

[1] Soochow Univ, Inst Biol, Suzhou 215123, Peoples R China

[2] Soochow Univ, Inst Med Sci, Suzhou 215123, Peoples R China

[3] Life Sci Inst, Hangzhou 310058, Zhejiang, Peoples R China

[4] Innovat Ctr Cell Signaling Network, Hangzhou 310058, Zhejiang, Peoples R China

[5] Pinghu Food & Drug Inspect Ctr, Pinghu 314200, Zhejiang, Peoples R China

来源：

ADVANCED SCIENCE | 2020年 / 7卷 / 20期

关键词：

biology; clinical symptoms; immune responses; SARS-CoV-2; therapeutic treatment; RESPIRATORY SYNDROME CORONAVIRUS; PAPAIN-LIKE PROTEASE; SPIKE PROTEIN; I INTERFERON; CLINICAL CHARACTERISTICS; CONVALESCENT PLASMA; CYTOKINE STORM; COVID-19; DOMAIN; VIRUS;

D O I：

10.1002/advs.202001474

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The world is currently experiencing a global pandemic caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes severe respiratory disease similar to SARS. Previous studies have suggested that SARS-CoV-2 shares 79% and 96% sequence identity to SARS-CoV and to bat coronavirus RaTG13, respectively, at the whole-genome level. Furthermore, a series of studies have shown that SARS-CoV-2 induces clusters of severe respiratory illnesses (i.e., pneumonia, acute lung injury, acute respiratory distress syndrome) resembling SARS-CoV. Moreover, the pathological syndrome may, in part, be caused by cytokine storms and dysregulated immune responses. Thus, in this work the recent literature surrounding the biology, clinical manifestations, and immunology of SARS-CoV-2 is summarized, with the aim of aiding prevention, diagnosis, and treatment for SARS-CoV-2 infection.

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