Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease

被引：11

作者：

Tan, E. K. ^{[1
,2
,3
]}

Lee, J. ^{[1
]}

Chen, C. P. ^{[1
,4
]}

Wong, M. C. ^{[1
,2
]}

Zhao, Y. ^{[1
]}

机构：

[1] Singapore Gen Hosp, Dept Neurol, Singapore 169608, Singapore

[2] Natl Inst Neurosci, Singapore, Singapore

[3] SingHealth, Singapore, Singapore

[4] Natl Univ Singapore, Singapore 117548, Singapore

来源：

NEUROBIOLOGY OF AGING | 2009年 / 30卷 / 03期

基金：

英国医学研究理事会;

关键词：

Alzheimer's disease; Gene; Variant; PARKINSONS-DISEASE; VARIANT;

D O I：

10.1016/j.neurobiolaging.2007.07.010

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Alzheimer's disease (AD) pathology has been described in Parkinson's disease (PD) patients with leucine-rich repeat kinase-2 (LRRK2) mutations. A common LRRK2 Gly2385Arg variant has been widely shown to be associated with a twofold increased risk of PD in various Asian populations. In a case control study, the frequency of the heterozygous Gly2385Arg genotype was demonstrated in 4.3% of AD compared to 4.5% in controls (odds ratio = 0.94, 95% CI 0.37-2.42, p = 1.0). The Gly2385Arg variant does not appear to modulate the risk of AD in our population. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：501 / 502

页数：2

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