Genetic Analysis of Primaquine Tolerance in Patient with Relapsing Vivax Malaria

被引：23

作者：

Bright, A. Taylor ^{[1
]}

Alenazi, Thamer ^{[3
,4
]}

Shokoples, Sandra ^{[5
]}

Tarning, Joel ^{[6
]}

Paganotti, Giacomo M. ^{[7
]}

White, Nicholas J. ^{[6
]}

Houston, Stanley ^{[3
,4
]}

Winzeler, Elizabeth A. ^{[2
]}

Yanow, Stephanie K. ^{[5
,8
]}

机构：

[1] Univ Calif San Diego, Biomed Sci Program, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, La Jolla, CA 92093 USA

[3] Univ Alberta Hosp, Edmonton, AB T6G 2B7, Canada

[4] King Saud bin Abdulaziz Univ Hlth Sci, Riyadh, Saudi Arabia

[5] Prov Lab Publ Hlth, Edmonton, AB T6G 2J2, Canada

[6] Univ Oxford, Oxford, England

[7] Univ Roma La Sapienza, I-00185 Rome, Italy

[8] Univ Alberta, Edmonton, AB, Canada

来源：

EMERGING INFECTIOUS DISEASES | 2013年 / 19卷 / 05期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

RESISTANCE; CHLOROQUINE;

D O I：

10.3201/eid1905.121852

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.

引用

页码：802 / 805

页数：4

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