Genetic Analysis of Primaquine Tolerance in Patient with Relapsing Vivax Malaria

被引：23

作者：

Bright, A. Taylor ^{[1
]}

Alenazi, Thamer ^{[3
,4
]}

Shokoples, Sandra ^{[5
]}

Tarning, Joel ^{[6
]}

Paganotti, Giacomo M. ^{[7
]}

White, Nicholas J. ^{[6
]}

Houston, Stanley ^{[3
,4
]}

Winzeler, Elizabeth A. ^{[2
]}

Yanow, Stephanie K. ^{[5
,8
]}

机构：

[1] Univ Calif San Diego, Biomed Sci Program, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, La Jolla, CA 92093 USA

[3] Univ Alberta Hosp, Edmonton, AB T6G 2B7, Canada

[4] King Saud bin Abdulaziz Univ Hlth Sci, Riyadh, Saudi Arabia

[5] Prov Lab Publ Hlth, Edmonton, AB T6G 2J2, Canada

[6] Univ Oxford, Oxford, England

[7] Univ Roma La Sapienza, I-00185 Rome, Italy

[8] Univ Alberta, Edmonton, AB, Canada

来源：

EMERGING INFECTIOUS DISEASES | 2013年 / 19卷 / 05期

基金：

英国惠康基金; 美国国家卫生研究院;

关键词：

RESISTANCE; CHLOROQUINE;

D O I：

10.3201/eid1905.121852

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.

引用

页码：802 / 805

页数：4

共 15 条

[1] Resistance to Therapies for Infection by Plasmodium vivax [J].

Baird, J. Kevin .

CLINICAL MICROBIOLOGY REVIEWS, 2009, 22 (03) :508-534

[2] CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants [J].

Bradford, LD .

PHARMACOGENOMICS, 2002, 3 (02) :229-243

[3] Relapse of imported vivax malaria despite standard-dose primaquine therapy: an investigation with molecular genotyping analyses [J].

Chiang, T-Y ;

Lin, W-C. ;

Kuo, M-C. ;

Ji, D-D. ;

Fang, C-T. .

CLINICAL MICROBIOLOGY AND INFECTION, 2012, 18 (07) :E232-E234

[4] The International Limits and Population at Risk of Plasmodium vivax Transmission in 2009 [J].

Guerra, Carlos A. ;

Howes, Rosalind E. ;

Patil, Anand P. ;

Gething, Peter W. ;

Van Boeckel, Thomas P. ;

Temperley, William H. ;

Kabaria, Caroline W. ;

Tatem, Andrew J. ;

Manh, Bui H. ;

Elyazar, Iqbal R. F. ;

Baird, J. Kevin ;

Snow, Robert W. ;

Hay, Simon I. .

PLOS NEGLECTED TROPICAL DISEASES, 2010, 4 (08)

[5] Primaquine: Report from CDC expert meeting on malaria chemoprophylaxis I [J].

Hill, David R. ;

Baird, J. Kevin ;

Parise, Monica E. ;

Lewis, Linda S. ;

Ryan, Edward T. ;

Magill, Alan J. .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2006, 75 (03) :402-415

[6] Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria [J].

Kublin, JG ;

Dzinjalamala, FK ;

Kamwendo, DD ;

Malkin, EM ;

Cortese, JF ;

Martino, LM ;

Mukadam, RAG ;

Rogerson, SJ ;

Lescano, AG ;

Molyneux, ME ;

Winstanley, PA ;

Chimpeni, P ;

Taylor, TE ;

Plowe, CV .

JOURNAL OF INFECTIOUS DISEASES, 2002, 185 (03) :380-388

[7] Multiple transporters associated with malaria parasite responses to chloroquine and quinine [J].

Mu, JB ;

Ferdig, MT ;

Feng, XR ;

Joy, DA ;

Duan, JH ;

Furuya, T ;

Subramanian, G ;

Aravind, L ;

Cooper, RA ;

Wootton, JC ;

Xiong, M ;

Su, XZ .

MOLECULAR MICROBIOLOGY, 2003, 49 (04) :977-989

[8] The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum [J].

Neafsey, Daniel E. ;

Galinsky, Kevin ;

Jiang, Rays H. Y. ;

Young, Lauren ;

Sykes, Sean M. ;

Saif, Sakina ;

Gujja, Sharvari ;

Goldberg, Jonathan M. ;

Young, Sarah ;

Zeng, Qiandong ;

Chapman, Sinead B. ;

Dash, Aditya P. ;

Anvikar, Anupkumar R. ;

Sutton, Patrick L. ;

Birren, Bruce W. ;

Escalante, Ananias A. ;

Barnwell, John W. ;

Carlton, Jane M. .

NATURE GENETICS, 2012, 44 (09) :1046-+

[9] Human Genetic Variation Is Associated With Plasmodium falciparum Drug Resistance [J].

Paganotti, Giacomo M. ;

Gallo, Baba C. ;

Verra, Federica ;

Sirima, Bienvenu S. ;

Nebie, Issa ;

Diarra, Amidou ;

Coluzzi, Mario ;

Modiano, David .

JOURNAL OF INFECTIOUS DISEASES, 2011, 204 (11) :1772-1778

[10] New developments in Plasmodium vivax malaria: severe disease and the rise of chloroquine resistance [J].

Price, Ric N. ;

Douglas, Nicholas M. ;

Anstey, Nicholas M. .

CURRENT OPINION IN INFECTIOUS DISEASES, 2009, 22 (05) :430-435

← 1 2 →