A new look at an old drug for the treatment of cancer cachexia: Megestrol acetate

被引：46

作者：

Argiles, Josep M. ^{[1
,2
]}

Anguera, Anna ^{[3
]}

Stemmler, Britta ^{[4
]}

机构：

[1] Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, Canc Res Grp, E-08028 Barcelona, Spain

[2] Univ Barcelona, Inst Biomed, E-08028 Barcelona, Spain

[3] Rottapharm SL, Barcelona, Spain

[4] BSA Nutr Ctr, Barcelona, Spain

来源：

CLINICAL NUTRITION | 2013年 / 32卷 / 03期

关键词：

Megestrol acetate; Cancer cachexia; Skeletal muscle; III CLINICAL-TRIAL; SKELETAL-MUSCLE; MEDROXYPROGESTERONE ACETATE; WEIGHT-LOSS; ANOREXIA; ANOREXIA/CACHEXIA; THERAPY; INTERLEUKIN-15; CHEMOTHERAPY; INVOLVEMENT;

D O I：

10.1016/j.clnu.2013.01.004

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Cachexia is a multiorganic syndrome associated with cancer, characterized by body weight loss, muscle and adipose tissue wasting and inflammation, being often associated with anorexia. The aim of the present review is to examine the impact of megestrol acetate in the treatment of cancer cachexia, both at the biochemical and physiological level taking into account new experimental data related to protein muscle metabolism. Based on experimental evidence, it is concluded that megestrol acetate is a good candidate for muscle wasting treatment and future studies addressed at the interaction between the drug and protein turnover in human skeletal muscle should be performed. (C) 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

引用

页码：319 / 324

页数：6

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