Effect of Variants of Penicillin-Binding Protein 2 on Cephalosporin and Carbapenem Susceptibilities in Neisseria gonorrhoeae

被引：12

作者：

Bharat, Amrita ^{[1
]}

Demczuk, Walter ^{[1
]}

Martin, Irene ^{[1
]}

Mulvey, Michael R. ^{[1
]}

机构：

[1] Publ Hlth Agcy Canada, Bacteriol & Enter Dis Program, Natl Microbiol Lab, Winnipeg, MB, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 08期

关键词：

HIGH-LEVEL RESISTANCE; REDUCED SUSCEPTIBILITY; PENA GENE; CEFIXIME; CEFTRIAXONE; ERTAPENEM; FAILURE; SPREAD; STRAIN; ERA;

D O I：

10.1128/AAC.05143-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To characterize the relationship between penicillin-binding protein 2 (PBP2/penA) and susceptibility to extended-spectrum cephalosporins (ESCs) and carbapenem antibiotics, we compared 17 PBP2 variants in Neisseria gonorrhoeae. Nonmosaic and mosaic variants of PBP2 caused decreased susceptibility to ESCs and, to a lesser extent, to carbapenems. An A501P substitution in mosaic XXXIV_A501P conferred decreased susceptibility to ESCs but restored carbapenem susceptibility to wild-type levels. These results could aid the molecular surveillance of antimicrobial resistance to these agents.

引用

页码：5003 / 5006

页数：4

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