Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline forCYP2C9andHLA-BGenotypes and Phenytoin Dosing: 2020 Update

被引：103

作者：

Karnes, Jason H. ^{[1
,2
]}

Rettie, Allan E. ^{[3
]}

Somogyi, Andrew A. ^{[4
]}

Huddart, Rachel ^{[5
]}

Fohner, Alison E. ^{[6
,7
]}

Formea, Christine M. ^{[8
]}

Ta Michael Lee, Ming ^{[9
]}

Llerena, Adrian ^{[10
]}

Whirl-Carrillo, Michelle ^{[5
]}

Klein, Teri E. ^{[5
,11
]}

Phillips, Elizabeth J. ^{[12
]}

Mintzer, Scott ^{[13
]}

Gaedigk, Andrea ^{[14
,15
]}

Caudle, Kelly E. ^{[16
]}

Callaghan, John T. ^{[17
,18
,19
]}

机构：

[1] Univ Arizona, Coll Pharm, Dept Pharm Practice & Sci, Tucson, AZ 85721 USA

[2] Univ Arizona, Coll Med, Sarver Heart Ctr, Tucson, AZ USA

[3] Univ Washington, Sch Pharm, Dept Med Chem, Seattle, WA 98195 USA

[4] Univ Adelaide, Adelaide Med Sch, Discipline Pharmacol, Adelaide, SA, Australia

[5] Stanford Univ, Dept Biomed Data Sci, Stanford, CA 94305 USA

[6] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[7] Univ Washington, Inst Publ Hlth Genet, Seattle, WA 98195 USA

[8] Intermt Healthcare, Dept Pharm & Intermt Precis Genom, Salt Lake City, UT USA

[9] Geisinger Hlth Syst, Genom Med Inst, Danville, PA USA

[10] INUBE Extremadura Univ Biosanitary Res Inst & Med, Badajoz, Spain

[11] Stanford Univ, Dept Med, Stanford, CA 94305 USA

[12] Vanderbilt Univ, Med Ctr, Dept Med, Div Infect Dis, Nashville, TN USA

[13] Thomas Jefferson Univ Hosp, Dept Neurol, Methodist Hosp Div, Philadelphia, PA 19107 USA

[14] Childrens Mercy Kansas City, Div Clin Pharmacol Toxicol & Therapeut Innovat, Kansas City, MO USA

[15] Univ Missouri, Sch Med, Kansas City, MO 64108 USA

[16] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, 332 N Lauderdale St, Memphis, TN 38105 USA

[17] Indiana Univ Sch Med, Dept Vet Affairs, Indianapolis, IN 46202 USA

[18] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA

[19] Indiana Univ Sch Med, Dept Pharmacol Toxicol, Indianapolis, IN 46202 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2021年 / 109卷 / 02期

基金：

澳大利亚国家健康与医学研究理事会; 美国国家卫生研究院; 英国医学研究理事会;

关键词：

STEVENS-JOHNSON-SYNDROME; HLA-B; ANTIEPILEPTIC DRUGS; GENOTYPE; POLYMORPHISMS; CYP2C9; CARBAMAZEPINE; RISK;

D O I：

10.1002/cpt.2008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Phenytoin is an antiepileptic drug with a narrow therapeutic index and large interpatient pharmacokinetic variability, partly due to genetic variation inCYP2C9. Furthermore, the variant alleleHLA-B*15:02is associated with an increased risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in response to phenytoin treatment. We summarize evidence from the published literature supporting these associations and provide therapeutic recommendations for the use of phenytoin based onCYP2C9and/orHLA-Bgenotypes (updates on cpicpgx.org).

引用

页码：302 / 309

页数：8

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