S100A12: A noninvasive marker of inflammation in inflammatory bowel disease

被引:44
作者
van de Logt, Floor [1 ]
Day, Andrew S. [1 ]
机构
[1] Univ Otago Christchurch, Dept Paediat, Christchurch 8140, New Zealand
关键词
children; fecal marker; inflammation; inflammatory bowel disease; S100A12; SUBCLINICAL INTESTINAL INFLAMMATION; CROHNS-DISEASE; FECAL S100A12; SERUM S100A12; CHILDREN; CALPROTECTIN; OUTCOMES; ONSET; RAGE;
D O I
10.1111/1751-2980.12012
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Inflammatory bowel diseases are incurable conditions that feature gut inflammation. Standard markers have inadequate sensitivity and specificity. S100A12 is a new fecal marker that has promise as a non-invasive indicator of gut inflammation. This article reviews recent studies focusing on S100A12 and highlights the current and potential roles of this biomarker.
引用
收藏
页码:62 / 67
页数:6
相关论文
共 35 条
[1]  
[Anonymous], 2007, J PEDIATR GASTR NUTR, V44, P653
[2]  
Belessis Y, 2006, RESPIROLOGY S2, V11, pA59
[3]   Polymeric diet alone versus corticosteroids in the treatment of active pediatric Crohn's disease: A randomized controlled open-label trial [J].
Borrelli, Osvaldo ;
Cordischi, Letizia ;
Cirulli, Manuela ;
Paganelli, Massimiliano ;
Labalestra, Valeria ;
Uccini, Stefania ;
Russo, Paolo M. ;
Cucchiara, Salvatore .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2006, 4 (06) :744-753
[4]   Early Mucosal Healing With Infliximab Is Associated With Improved Long-term Clinical Outcomes in Ulcerative Colitis [J].
Colombel, Jean Frederic ;
Rutgeerts, Paul ;
Reinisch, Walter ;
Esser, Dirk ;
Wang, Yanxin ;
Lang, Yinghua ;
Marano, Colleen W. ;
Strauss, Richard ;
Oddens, Bjoern J. ;
Feagan, Brian G. ;
Hanauer, Stephen B. ;
Lichtenstein, Gary R. ;
Present, Daniel ;
Sands, Bruce E. ;
Sandborn, William J. .
GASTROENTEROLOGY, 2011, 141 (04) :1194-1201
[5]   Fecal S100A12: A novel noninvasive marker in children with Crohn's disease [J].
de Jong, Naomi S. H. ;
Leach, Steven T. ;
Day, Andrew S. .
INFLAMMATORY BOWEL DISEASES, 2006, 12 (07) :566-572
[6]   Review article: biological activity markers in inflammatory bowel disease [J].
Desai, D. ;
Faubion, W. A. ;
Sandborn, W. J. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2007, 25 (03) :247-255
[7]   Intracellular and extracellular roles of s100 proteins [J].
Donato, R .
MICROSCOPY RESEARCH AND TECHNIQUE, 2003, 60 (06) :540-551
[8]  
Escher JC, 2005, J PEDIATR GASTR NUTR, V41, P1
[9]   FECAL ALPHA-1-ANTITRYPSIN AND EXCRETION OF IN-111 GRANULOCYTES IN ASSESSMENT OF DISEASE-ACTIVITY IN CHRONIC INFLAMMATORY BOWEL DISEASES [J].
FISCHBACH, W ;
BECKER, W ;
MOSSNER, J ;
KOCH, W ;
REINERS, C .
GUT, 1987, 28 (04) :386-393
[10]   Mucosal healing in Crohn's disease and ulcerative colitis: what does it tell us? [J].
Flynn, Ann ;
Kane, Sunanda .
CURRENT OPINION IN GASTROENTEROLOGY, 2011, 27 (04) :342-345