Chronic spontaneous urticaria: an autoimmune disease? A revision of the literature

被引：11
作者：
Di Lorenzo, Gabriele [1 ]
Leto-Barone, Maria Stefania [1 ]
La Piana, Simona [2 ]
Seidita, Aurelio [1 ]
Rini, Giovam Battista [1 ]
机构：
[1] Univ Palermo, Dipartimento Med Interna & Specialist DIMIS, I-90127 Palermo, Italy
[2] Univ Palermo, Dipartimento Biopatol & Biotecnol Med & Forensi, I-90127 Palermo, Italy
来源：
CLINICAL AND EXPERIMENTAL MEDICINE | 2013年 / 13卷 / 03期
关键词：
Urticaria; Histamine-releasing autoantibodies; Autologous serum skin test; Basophils; CHRONIC IDIOPATHIC URTICARIA; SERUM SKIN-TEST; FC-EPSILON-RI; AUTOLOGOUS SERUM; HISTAMINE-RELEASE; SEROLOGICAL MEDIATOR; THYROID AUTOIMMUNITY; IGG AUTOANTIBODIES; ANTI-IGE; CLASSIFICATION;
D O I：
10.1007/s10238-012-0188-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The cause of chronic spontaneous urticaria has been an enigma for decades, but the recognition of functional autoantibodies in some patients with the spontaneous chronic urticaria has opened up a new concept of autoimmune urticaria. Clinical and laboratory features are in keeping with an autoimmune aetiology for many patients with otherwise inexplicable disease, but there is still debate about the importance of functional autoantibodies in the disease pathogenesis, how to test them and the clinical implications for treatment and prognosis. This review will look at the evidence for there being an autoimmune subset of urticaria, the strengths and weaknesses of the available tests in current use.
引用
收藏
页码：159 / 164
页数：6
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