Pathophysiology of Food Allergy

被引：17

作者：

Pelz, Barry J. ^{[1
]}

Bryce, Paul J. ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Div Allergy Immunol, Chicago, IL 60611 USA

来源：

PEDIATRIC CLINICS OF NORTH AMERICA | 2015年 / 62卷 / 06期

关键词：

Food allergy; Pathophysiology; Oral tolerance; Sensitization; IgE; REGULATORY T-CELLS; THYMIC STROMAL LYMPHOPOIETIN; FC-GAMMA RIII; PEANUT ALLERGY; ORAL TOLERANCE; DENDRITIC CELLS; SYSTEMIC-ANAPHYLAXIS; TH2; DIFFERENTIATION; UNITED-STATES; MURINE MODEL;

D O I：

10.1016/j.pcl.2015.07.004

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Food allergy is a growing public health problem that is estimated to affect 4% to 8% of children and 5% of adults. In this review, we discuss our current understanding of the pathophysiology of food allergy, from oral tolerance, to sensitization, and lastly the elicitation of an allergic response. As much of the existing evidence for the mechanisms of food allergy is derived from animal models, we include these studies where relevant. In addition, whenever possible, we review similar evidence involved in human disease and provide applications for consideration in clinical practice.

引用

页码：1363 / +

页数：14

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