Ovarian ascites-derived Hospicells promote angiogenesis via activation of macrophages

被引：35

作者：

Castells, Magali ^{[1
,2
]}

Thibault, Benoit ^{[1
,2
]}

Mery, Eliane ^{[1
]}

Golzio, Muriel ^{[2
,3
]}

Pasquet, Marlene ^{[1
]}

Hennebelle, Isabelle ^{[1
]}

Bourin, Philippe ^{[4
]}

Mirshahi, Massoud ^{[5
]}

Delord, Jean Pierre ^{[1
]}

Querleu, Denis ^{[1
]}

Couderc, Bettina ^{[1
,2
]}

机构：

[1] Inst Claudius Regaud, EA4553, F-31062 Toulouse, France

[2] Univ Toulouse 3, F-31052 Toulouse, France

[3] Ctr Natl Rech Sci, Inst Pharmacol & Biol Struct, F-31077 Toulouse, France

[4] Etab Francais Sang Pyrenees Mediterranee, Serv Ingn Cellulaire, F-31300 Toulouse, France

[5] INSERM, UMR 736, F-75000 Paris, France

来源：

CANCER LETTERS | 2012年 / 326卷 / 01期

关键词：

Ovarian cancer; CA-MSC; Cytokines; Angiogenesis; Macrophages; MESENCHYMAL STEM-CELLS; CANCER CELLS; ONCOLOGIC TROGOCYTOSIS; TUMOR PROGRESSION; EXPRESSION; CARCINOMA; DIFFERENTIATION; STROMA; FIBROBLASTS; CONTRIBUTES;

D O I：

10.1016/j.canlet.2012.07.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Within the microenvironment, Carcinoma-associated mesenchymal stem cells (Hospicells) are able to influence ovarian tumor development via, among others, the facilitation of angiogenesis in the tumor site allowing an accelerated tumor growth. We demonstrate the presence of a chemotactism between endothelial cells and Hospicells, and a cell line specific increased secretion of pro-angiogenic cytokines such as IL-6, IL-8 and VEGF from ovarian adenocarcinoma cells. Hospicells are also able to attract and activate macrophages to a M2 phenotype and allow them to secrete a huge quantity of pro-angiogenic cytokines, favorable to tumor progression of all the associated ovarian adenocarcinoma cells tested. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：59 / 68

页数：10

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