Management of epilepsy associated with tuberous sclerosis complex (TSC): Clinical recommendations

被引：130

作者：

Curatolo, Paolo ^{[1
]}

Jozwiak, Sergiusz ^{[2
]}

Nabbout, Rima ^{[3
]}

机构：

[1] Univ Roma Tor Vergata, Dept Neurosci, Pediat Neurol Unit, I-00133 Rome, Italy

[2] Childrens Mem Hlth Inst, Dept Neurol & Epileptol, Warsaw, Poland

[3] Hop Necker Enfants Malad, Dept Neuropediat, Ctr Reference Epilepsies Rares, Paris, France

来源：

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY | 2012年 / 16卷 / 06期

关键词：

Epilepsy; Tuberous sclerosis complex (TSC); Consensus; Clinical recommendations; mTOR; VAGUS NERVE-STIMULATION; INTRACTABLE EPILEPSY; INFANTILE SPASMS; MOUSE MODEL; SEIZURES; VIGABATRIN; EVEROLIMUS; CHILDREN; SURGERY;

D O I：

10.1016/j.ejpn.2012.05.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tuberous sclerosis complex (TSC) is a leading genetic cause of epilepsy. TSC-associated epilepsy generally begins during the first year of life, and is associated with neurodevelopmental and cognitive problems. Management is challenging and seizures tend to persist in a large proportion of patients despite pharmacological and surgical treatment. This report summarizes the clinical recommendations for the management of TSC-associated epilepsy made by a panel of European experts in March 2012. Current treatment options and outstanding questions are outlined. (C) 2012 Published by Elsevier Ltd on behalf of European Paediatric Neurology Society.

引用

页码：582 / 586

页数：5

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