Vasopressin/Oxytocin-Related Signaling Regulates Gustatory Associative Learning in C. elegans

被引：124

作者：

Beets, Isabel ^{[1
]}

Janssen, Tom ^{[1
]}

Meelkop, Ellen ^{[1
]}

Temmerman, Liesbet ^{[1
]}

Suetens, Nick ^{[1
]}

Rademakers, Suzanne ^{[2
]}

Jansen, Gert ^{[2
]}

Schoofs, Liliane ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Biol, Funct Genom & Prote Unit, B-3000 Louvain, Belgium

[2] Erasmus MC, Dept Cell Biol, NL-3000 CA Rotterdam, Netherlands

来源：

SCIENCE | 2012年 / 338卷 / 6106期

关键词：

CAENORHABDITIS-ELEGANS; OXYTOCIN RECEPTORS; IDENTIFICATION; PLASTICITY; MOTIVATION; SEROTONIN; DOPAMINE; CUES;

D O I：

10.1126/science.1226860

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Vasopressin- and oxytocin-related neuropeptides are key regulators of animal physiology, including water balance and reproduction. Although these neuropeptides also modulate social behavior and cognition in mammals, the mechanism for influencing behavioral plasticity and the evolutionary origin of these effects are not well understood. Here, we present a functional vasopressin- and oxytocin-like signaling system in the nematode Caenorhabditis elegans. Through activation of its receptor NTR-1, a vasopressin/oxytocin-related neuropeptide, designated nematocin, facilitates the experience-driven modulation of salt chemotaxis, a type of gustatory associative learning in C. elegans. Our study suggests that vasopressin and oxytocin neuropeptides have ancient roles in modulating sensory processing in neural circuits that underlie behavioral plasticity.

引用

页码：543 / 545

页数：3

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