Which GABA(A)-receptor subtypes really occur in the brain?

被引：1060
作者：
McKernan, RM
Whiting, PJ
机构：
[1] Dept of Biochem. and Molec. Biology, Neuroscience Research Centre, Merck Sharp and Dohme Res. Labs., Harlow, Essex CM20 2QR, Terlings Park, Eastwick Rd
来源：
TRENDS IN NEUROSCIENCES | 1996年 / 19卷 / 04期
关键词：
D O I：
10.1016/S0166-2236(96)80023-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
GABA(A) receptors are a heterogeneous family of ligand-gated ion channels responsible for mediating inhibitory neurotransmission in the CNS. Since the identification of mammalian cDNAs encoding 13 GABA(A)-receptor subunits, the composition of native receptor molecules and their localization in the brain has been an area of intense study. We conclude that the number of major subtypes is probably less than ten but their physiological roles have yet to be clearly defined and this represents the next step in GABA(A)-receptor research.
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页码：139 / 143
页数：5
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