Acute lymphoblastic leukaemia occurring as second malignancy: report of the GIMEMA Archive of Adult Acute Leukaemia

被引：68

作者：

Pagano, L

Pulsoni, A

Tosti, ME

Annino, L

Mele, A

Camera, A

Martino, B

Guglielmi, C

Cerri, R

Di Bona, E

Invernizzi, R

Castagnola, C

Bassan, R

Mele, L

Todeschini, G

Leone, G

Mandelli, F

机构：

[1] Univ Cattolica Sacro Cuore, Dept Haematol, I-00168 Rome, Italy

[2] Osped Riuniti, Div Ematol, Reggio Di Calabria, Italy

[3] Univ Roma La Sapienza, Cattedra Ematol, Rome, Italy

[4] Univ Naples Federico 2, Ist Ematol, Naples, Italy

[5] Univ Ancona, Ist Ematol, I-60128 Ancona, Italy

[6] Ist Super Sanita, Reparto Epidemiol Clin, I-00161 Rome, Italy

[7] Osped San Martino Genova, Genoa, Italy

[8] Policlin San Matteo, Div Ematol, I-27100 Pavia, Italy

[9] Osped S Bortolo, Div Ematol, Vicenza, Italy

[10] Univ Pavia, Ist Clin Med 2, I-27100 Pavia, Italy

[11] Osped Riuniti Bergamo, Div Ematol, I-24100 Bergamo, Italy

[12] Univ Verona, Policlin Borgo Roma, I-37134 Verona, Italy

[13] Osped Cremona, Sez Ematol, Cremona, Italy

[14] Osped Nuovo Pellegrini, Div Ematol, Naples, Italy

[15] Univ Roma Tor Vergata, Cattedra Ematol, Rome, Italy

[16] Univ Ferrara, Cattedra Ematol, I-44100 Ferrara, Italy

[17] Univ Parma, Cattedra Ematol, I-43100 Parma, Italy

[18] Osped Civile, Div Ematol, Pescara, Italy

[19] Arcispedale S Maria Nuova, Div Med, Reggio Emilia, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1999年 / 106卷 / 04期

关键词：

secondary acute lymphoblastic leukaemia; primary malignancy; epidemiology;

D O I：

10.1046/j.1365-2141.1999.01636.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Between July 1992 and Tune 1996, 901 new cases of adult acute lymphoblastic leukaemia were recorded in the GIMEMA Archive of Adult Acute Leukaemia; 21 of them (2.3%) had a previous primary malignancy (PM). We found that secondary acute lymphoblastic leukaemia cases (sALL) presented with older age, a high incidence of pre-pre-B immunophenotype and a significantly higher prevalence of cancer among relatives compared to de novo ALL. The leukaemogenic activity of the cytotoxic drugs employed for the treatment of PM may have played a potential role in only a proportion of patients, opening the possibility that some sALL patients may have developed two or more malignancies due to individual predisposing factors.

引用

页码：1037 / 1040

页数：4

共 13 条

[1] ACUTE-LEUKEMIA WITH T(4-11) IN PATIENTS PREVIOUSLY EXPOSED TO CARCINOGENS [J].