Salmonella infections in the mouse model:: host resistance factors and in vivo dynamics of bacterial spread and distribution in the tissues

被引：74
作者：
Mastroeni, P [1 ]
Sheppard, M [1 ]
机构：
[1] Univ Cambridge, Ctr Vet Sci, Cambridge CB3 0ES, England
来源：
MICROBES AND INFECTION | 2004年 / 6卷 / 04期
关键词：
Salmonella; infection; immunity; microscopy; macrophages;
D O I：
10.1016/j.micinf.2003.12.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The mouse model is widely used to study the mechanisms of the pathogenesis of, and immunity to, systemic salmonellosis. During infection, Salmonella grows in phagocytic cells that reside in well-defined pathological lesions, are activated by cytokines and control the growth of intracellular bacteria using oxygen and nitrogen derivatives. Salmonella growth in the tissues results in the spatial segregation of bacterial populations and in their continuous distribution to new phagocytes. High bacterial numbers within infected phagocytes are uncommon in vivo. (C) 2004 Elsevier SAS. All rights reserved.
引用
收藏
页码：398 / 405
页数：8
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