Antiretroviral treatment and its impact on oral health outcomes in 5 to 7 year old Ugandan children A 6 year follow-up visit from the ANRS 12174 randomized trial

被引：5

作者：

Birungi, Nancy ^{[1
]}

Fadnes, Lars T. ^{[3
,4
]}

Engebretsen, Ingunn M. S. ^{[2
]}

Tumwine, James K. ^{[5
]}

Astrom, Anne Nordrehaug ^{[1
]}

Van de Perre, Philippe ^{[6
]}

Nagot, Nicolas ^{[6
]}

Moles, Jean-Pierre ^{[6
]}

Quillet, Catherine ^{[6
]}

Vallo, Roselyne ^{[6
]}

Marechal, Valerie ^{[6
]}

Peries, Marianne ^{[6
]}

Neveu, Dorine ^{[6
]}

Foulongne, Vincent ^{[6
]}

Segondy, Michel ^{[6
]}

Blanche, Stephane ^{[7
]}

Treluyer, Jean-Marc ^{[7
]}

Hirt, Deborah ^{[7
]}

Ndeezi, Grace ^{[8
]}

Karamagi, Charles ^{[8
]}

Musoke, Philippa ^{[8
]}

Bangirana, Paul ^{[8
]}

Mugaba, Proscovia M. ^{[8
]}

Kwagala, Mary ^{[8
]}

Nalugya, Joyce ^{[8
]}

Murungi, Joan ^{[8
]}

Abeso, Julian ^{[8
]}

Baryeija, Simon ^{[8
]}

Juma, Frederic ^{[8
]}

Kanyago, Jesca ^{[8
]}

Muweesi, Hawa Nabuuma ^{[8
]}

Ninsiima, Evelyn ^{[8
]}

Mwesigwa, Daniel Prince ^{[8
]}

Kata, Caleb Bwengye ^{[8
]}

Katushabe, Stuart ^{[8
]}

Meda, Nicolas ^{[9
]}

Ouedraogo, Rasmata ^{[9
]}

Some, Eric ^{[9
]}

Tassembedo, Souleymane ^{[9
]}

Yamaego-Zoungrana, Noelie ^{[9
]}

Ye, Diarra ^{[9
]}

Amoussou, Myriam ^{[9
]}

Dembele, Emmanuel ^{[9
]}

Neboua, Desire ^{[9
]}

Zongo, Aissatou Belemvire Arsene ^{[9
]}

Djiga, Binta ^{[9
]}

Sanfo, Lydia ^{[9
]}

Traore, Hugues A. ^{[9
]}

Nadembega, Christelle ^{[9
]}

Konate, Justin ^{[9
]}

机构：

[1] Univ Bergen, Dept Clin Dent, Bergen, Norway

[2] Univ Bergen, Dept Global Hlth & Primary Hlth Care, Bergen, Norway

[3] Univ Bergen, Ctr Int Hlth, Dept Global Hlth & Primary Hlth Care, Bergen, Norway

[4] Haukeland Hosp, Dept Addict Med, Bergen, Norway

[5] Makerere Univ Kampala, Dept Pediat & Child Hlth, Sch Med, Coll Hlth Sci, Kampala, Uganda

[6] Univ Montpellier, Inserm 1058, Montpellier, France

[7] Univ Paris V, Paris, France

[8] Makerere Univ, Kampala, Uganda

[9] Univ Ouagadougou, Ouagadougou, Burkina Faso

[10] Univ Western Cape, Cape Town, South Africa

来源：

MEDICINE | 2020年 / 99卷 / 39期

关键词：

antiretroviral; children; clinical trial; dental caries; gingivitis; oral health related quality of life; public health; DENTAL-CARIES; HIV; LOPINAVIR/RITONAVIR; ASSOCIATION; HAART;

D O I：

10.1097/MD.0000000000022352

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Antiretroviral therapy for HIV in sub-Saharan Africa has transformed the highly infectious virus to a stable chronic condition, with the advent of Highly active antiretroviral therapy (HAART). The longterm effects of HAART on the oral health of children are understudied. Objective: To compare the effect of lopinavir-ritonavir and lamivudine on oral health indicators (dental caries, gingivitis, tooth eruption, and oral health related quality of life) in 5 to 7 year old HIV-1 exposed uninfected children from the ANRS 12174 trial. Methods: This study used data collected in 2017 among children aged 5 to 7 years from the Ugandan site of the ANRS 12174 randomized trial (ClinicalTrials.gov no: NCT00640263) implemented between 2009 and 2012 in Mbale district, Eastern Uganda. The intervention was lopinavir-ritonavir or lamuvudine treatment to prevent vertical HIV-1 transmission. One hundred thirty-seven and 139 children were randomized to receive lopinavir-ritonavir or lamivudine treatment at day 7 postpartum to compare efficacy of prevention of vertical HIV-1 transmission. At follow up, the children underwent oral examination using the World Health Organization methods for field conditions. The oral health related quality of life was assessed using the early childhood oral health impact scale. Negative binomial and logistic regression were used for the analysis of data. Main outcome measures: Dental caries, gingivitis, tooth eruption, and oral health related quality of life) in 5 to 7 year old HIV-1 exposed uninfected children. Results: The prevalence of dental caries was 48% in the study sample: 49% in the lopinavir-ritonavir arm and 48% in the lamivudine treatment group. The corresponding mean decayed missing filled teeth and standard deviation was 1.7 (2.4) and 2.3 (3.7) The mean number (standard deviation) of erupted permanent teeth was 3.8 (3.7) and 4.6 (3.9) teeth in the lopinavir- and lamivudine group, respectively. The prevalence of reported impacts on oral health was 7% in the lopinavir-ritonavir and 18% in the lamivudine group. Gingivitis had a prevalence of 7% in the lopinavir-ritonavir and 14% lamivudine treatment group. The regression analysis revealed 70% less reported impacts on oral health in lopinavir-ritonavir group than the lamivudine treatment group with an incidence rate ratio of 0.3 (95% confidence interval: 0.1-0.9). Conclusions: HIV exposed uninfected infants in the lopinavir-ritonavir group reported less impacts on oral health than the lamivudine treatment group. Dental caries, gingivitis, and tooth eruption were not significantly affected by the treatment lopinavir-ritonavir or lamivudine.

引用

页数：8

共 25 条

[1]

[Anonymous], 2013, Oral health surveys: basic methods, V5th, P115

[2] Association of maternal HIV-1 severity with dental caries: an observational study of uninfected 5-to 7-yr-old children of HIV-1-infected mothers without severe immune suppression [J].