Intraductal Carcinoma of the Prostate Gland: Recent Advances

被引:15
作者
Divatia, Mukul K. [1 ]
Ro, Jae Y. [1 ]
机构
[1] Cornell Univ, Weill Med Coll, Houston Methodist Hosp, Dept Pathol & Genom Med, 6565 Fannin St, Houston, TX 77030 USA
关键词
Intraductal carcinoma of prostate; high-grade prostatic intraepithelial neoplasia; prostatic ductal adenocarcinoma; ATYPICAL CRIBRIFORM LESIONS; INTRAEPITHELIAL NEOPLASIA; RADICAL-PROSTATECTOMY; DUCTAL ADENOCARCINOMA; ENDOMETRIOID FEATURES; NEEDLE-BIOPSY; CANCER PROGRESSION; SPECIMENS; PATTERNS; ANTIBODY;
D O I
10.3349/ymj.2016.57.5.1054
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Intraductal carcinoma of the prostate (IDC-P) is characterized by prostatic carcinoma involving ducts and/or acini. The presence of IDC-P is usually associated with a high-grade Gleason score, large tumor volume, and adverse prognostic parameters, including extraprostatic extension and seminal vesicle invasion. When present, IDC-P is associated with worse outcomes, regardless of treatment status. IDC-P is included in a broader diagnostic category of atypical cribriform lesions of the prostate gland. This category of lesions also includes high-grade prostatic intraepithelial neoplasia (HGPIN), urothelial carcinoma involving prostatic ducts or acini, and prostatic ductal adenocarcinoma, amongst other intraductal proliferations. Differentiating between these entities is important as they have differing therapeutic and prognostic implications for patients, although differential diagnosis thereof is not always straightforward. The present review discusses IDC-P in regards to its morphological characteristics, molecular features, and clinical outcomes. Given the current state of knowledge, the presence of IDC-P should be evaluated and documented correctly in both radical prostatectomy and needle biopsy specimens, and the clinical implications thereof should be taken into consideration during treatment and follow up.
引用
收藏
页码:1054 / 1062
页数:9
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